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Chlorate’s Potential as a Pro-Drug for Killing Antibiotic-Tolerant Pathogens in the Cystic Fibrosis Lung

Spero, M. A. and Silveira, C. B. and Rohwer, F. and Newman, D. K. (2019) Chlorate’s Potential as a Pro-Drug for Killing Antibiotic-Tolerant Pathogens in the Cystic Fibrosis Lung. Pediatric Pulmonology, 54 (S2). S281. ISSN 8755-6863. https://resolver.caltech.edu/CaltechAUTHORS:20190926-131636762

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Abstract

Chronic lung infections are a major contributor to morbidity and mortality in cystic fibrosis (CF) patients. Perhaps the most notorious CF pathogen is Pseudomonas aeruginosa, which establishes decades-long lung infections despite aggressive antibiotic treatment. In part, drugs fail to clear P. aeruginosa lung infections because some pathogen populations exhibit antibiotic tolerance, a metabolic state that reduces a cell’s susceptibility to drugs. Antibiotic tolerance is associated with low metabolic activity, and P. aeruginosa growth is limited by oxygen availability in the largely hypoxic/anoxic CF sputum.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1002/ppul.22495DOIAbstracts
ORCID:
AuthorORCID
Spero, M. A.0000-0003-3291-2138
Newman, D. K.0000-0003-1647-1918
Additional Information:© 2019 Wiley Periodicals, Inc. First published: 05 September 2019.
Issue or Number:S2
Record Number:CaltechAUTHORS:20190926-131636762
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190926-131636762
Official Citation:(2019), Poster Session. Pediatr Pulmonol, 54: S155-S480. doi:10.1002/ppul.22495
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:98876
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:26 Sep 2019 21:06
Last Modified:20 Dec 2019 17:20

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