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The control of gene expression and cell identity by H3K9 trimethylation

Ninova, Maria and Fejes Tóth, Katalin and Aravin, Alexei A. (2019) The control of gene expression and cell identity by H3K9 trimethylation. Development, 146 (19). Art. No. dev181180 . ISSN 0950-1991. PMCID PMC6803365 . https://resolver.caltech.edu/CaltechAUTHORS:20190930-133755699

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Abstract

Histone 3 lysine 9 trimethylation (H3K9me3) is a conserved histone modification that is best known for its role in constitutive heterochromatin formation and the repression of repetitive DNA elements. More recently, it has become evident that H3K9me3 is also deposited at certain loci in a tissue-specific manner and plays important roles in regulating cell identity. Notably, H3K9me3 can repress genes encoding silencing factors, pointing to a fundamental principle of repressive chromatin auto-regulation. Interestingly, recent studies have shown that H3K9me3 deposition requires protein SUMOylation in different contexts, suggesting that the SUMO pathway functions as an important module in gene silencing and heterochromatin formation. In this Review, we discuss the role of H3K9me3 in gene regulation in various systems and the molecular mechanisms that guide the silencing machinery to target loci.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1242/dev.181180DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc6803365/PubMed CentralArticle
ORCID:
AuthorORCID
Ninova, Maria0000-0001-5051-5502
Fejes Tóth, Katalin0000-0001-6558-2636
Additional Information:© 2019. Published by The Company of Biologists Ltd. Published online September 20, 2019. We thank the three reviewers for the insightful comments and suggestions that helped us to improve this article. The role of H3K9me3 in various aspects of gene regulation is a broad topic and we apologize to colleagues whose relevant work was not discussed due to space limitations. The authors' research is supported by grants from the National Institutes of Health (R01 GM097363 to A.A.A. and R01 GM110217 to K.F.T.) and Minobrnauka of the Russian Federation (14.W03.31.0007), and by David and Lucile Packard Foundation Awards to A.A.A. Deposited in PMC for release after 12 months. The authors declare no competing or financial interests.
Funders:
Funding AgencyGrant Number
NIHR01 GM097363
NIHR01 GM110217
Ministry of Education and Science of the Russian Federation14.W03.31.0007
David and Lucile Packard FoundationUNSPECIFIED
Subject Keywords:Chromatin, Heterochromatin, Epigenetics, Gene regulation, Transcriptional repression, Transposons, Germline, Cell fate maintenance
Issue or Number:19
PubMed Central ID:PMC6803365
Record Number:CaltechAUTHORS:20190930-133755699
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190930-133755699
Official Citation:The control of gene expression and cell identity by H3K9 trimethylation Maria Ninova, Katalin Fejes Tóth, Alexei A. Aravin Development 2019 146: dev181180 doi: 10.1242/dev.181180 Published 20 September 2019
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:98949
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:30 Sep 2019 22:42
Last Modified:15 Apr 2020 16:51

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