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Abstract goal representation in visual search by neurons in the human pre-supplementary motor area

Wang, Shuo and Mamelak, Adam N. and Adolphs, Ralph and Rutishauser, Ueli (2019) Abstract goal representation in visual search by neurons in the human pre-supplementary motor area. Brain, 142 (11). pp. 3530-3549. ISSN 0006-8950. PMCID PMC6821249 . https://resolver.caltech.edu/CaltechAUTHORS:20190930-133756343

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Abstract

The medial frontal cortex is important for goal-directed behaviours such as visual search. The pre-supplementary motor area (pre-SMA) plays a critical role in linking higher-level goals to actions, but little is known about the responses of individual cells in this area in humans. Pre-SMA dysfunction is thought to be a critical factor in the cognitive deficits that are observed in diseases such as Parkinson’s disease and schizophrenia, making it important to develop a better mechanistic understanding of the pre-SMA’s role in cognition. We simultaneously recorded single neurons in the human pre-SMA and eye movements while subjects performed goal-directed visual search tasks. We characterized two groups of neurons in the pre-SMA. First, 40% of neurons changed their firing rate whenever a fixation landed on the search target. These neurons responded to targets in an abstract manner across several conditions and tasks. Responses were invariant to motor output (i.e. button press or not), and to different ways of defining the search target (by instruction or pop-out). Second, ∼50% of neurons changed their response as a function of fixation order. Together, our results show that human pre-SMA neurons carry abstract signals during visual search that indicate whether a goal was reached in an action- and cue-independent manner. This suggests that the pre-SMA contributes to goal-directed behaviour by flexibly signalling goal detection and time elapsed since start of the search, and this process occurs regardless of task. These observations provide insights into how pre-SMA dysfunction might impact cognitive function.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1093/brain/awz279DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc6821249/PubMed CentralArticle
ORCID:
AuthorORCID
Wang, Shuo0000-0003-2562-0225
Mamelak, Adam N.0000-0002-4245-6431
Adolphs, Ralph0000-0002-8053-9692
Rutishauser, Ueli0000-0002-9207-7069
Additional Information:© The Author(s) (2019). Published by Oxford University Press on behalf of the Guarantors of Brain. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Received February 6, 2019. Revised June 14, 2019. Accepted July 11, 2019. We thank all patients for their participation, and Nand Chandravadia for localizing recording sites. This research was supported by the Rockefeller Neuroscience Institute, the Autism Science Foundation and the Dana Foundation (to S.W.), the Simons Foundation (Simons Collaboration on the Global Brain Award 543015SPI to R.A.), an National Science Foundation CAREER award (1554105 to U.R.), and the National Institute of Mental Health (R01MH110831 to U.R. and Conte Center P50MH094258 to R.A.). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors report no competing interests.
Funders:
Funding AgencyGrant Number
Rockefeller Neuroscience InstituteUNSPECIFIED
Autism Science FoundationUNSPECIFIED
Dana FoundationUNSPECIFIED
Simons Foundation543015SPI
NSFBCS-1554105
NIHR01MH110831
NIHP50MH094258
National Institute of Mental Health (NIMH)UNSPECIFIED
Subject Keywords:human single unit, visual search, pre-supplementary motor area, target detection, abstract goal representation
Issue or Number:11
PubMed Central ID:PMC6821249
Record Number:CaltechAUTHORS:20190930-133756343
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190930-133756343
Official Citation:Shuo Wang, Adam N Mamelak, Ralph Adolphs, Ueli Rutishauser, Abstract goal representation in visual search by neurons in the human pre-supplementary motor area, Brain, 142(11): 3530-3549, https://doi.org/10.1093/brain/awz279
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:98953
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:30 Sep 2019 21:58
Last Modified:01 Apr 2020 21:49

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