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The pharmacology of selective estrogen receptor modulators: past and present

Markovac, Jasna and Marcus, Robert (2019) The pharmacology of selective estrogen receptor modulators: past and present. In: Principles of Bone Biology. Elsevier , London, pp. 863-893. ISBN 9780128148419.

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For many years, significant research was being conducted on the effects of selective estrogen receptor modulators (SERMs) on bone. Raloxifene successfully completed clinical trials and is currently prescribed for the prevention and treatment of osteoporosis. Other promising candidate molecules were going through clinical trials. However, in the past 10 years, since the publication of the third edition of this book, very little new information has been presented on the effects of SERMs on bone. Pharmaceutical companies have moved away from developing new antiresorptive drugs for osteoporosis, although some research is continuing on the potential usefulness of SERMs in the treatment of other conditions. Because the third edition contribution on this topic contains useful and still very valid information, much of this chapter represents a slightly edited version of that content.

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Additional Information:© 2020 Elsevier Inc. Available online 23 August 2019. Most of this chapter is an edited version of the chapter from the third edition of this book, written by Henry U. Bryant, Eli Lilly and Company, Indianapolis, IN.
Subject Keywords:Antiresorptive drugs; Estrogen receptors; Selective estrogen receptor modules; SERMs
Record Number:CaltechAUTHORS:20191007-112958990
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Official Citation:Jasna Markovac, Robert Marcus, Chapter 37 - The pharmacology of selective estrogen receptor modulators: past and present, Editor(s): John P. Bilezikian, T. John Martin, Thomas L. Clemens, Clifford J. Rosen, Principles of Bone Biology (Fourth Edition), Academic Press, 2020, Pages 863-893, ISBN 9780128148419, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:99112
Deposited By: Tony Diaz
Deposited On:07 Oct 2019 20:00
Last Modified:16 Nov 2021 17:43

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