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Tactile Responses in the Granule Cell Layer of Cerebellar Folium Crus IIa of Freely Behaving Rats

Hartmann, Mitra J. and Bower, James M. (2001) Tactile Responses in the Granule Cell Layer of Cerebellar Folium Crus IIa of Freely Behaving Rats. Journal of Neuroscience, 21 (10). pp. 3549-3563. ISSN 0270-6474. PMCID PMC6762470. https://resolver.caltech.edu/CaltechAUTHORS:20191009-081040948

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Abstract

We recorded activity from the granule cell layer (GCL) of cerebellar folium Crus IIa as freely moving rats engaged in a variety of natural behaviors, including grooming, eating, and free tactile exploration. Multiunit responses in the 1000–4500 Hz range were found to be strongly correlated with tactile stimulation of lip and whisker (perioral) regions. These responses occurred regardless of whether the stimulus was externally or self-generated and during both active and passive touch. In contrast, perioral movements that did not tactually stimulate this region of the face (e.g., chewing) produced no detectable increases in GCL activity. In addition, GCL responses were not correlated with movement extremes. When rats used their lips actively for palpation and exploration, the tactile responses in the GCL were not detectably modulated by ongoing jaw movements. However, active palpation and exploratory behaviors did result in the largest and most continuous bursts of GCL activity: responses were on average 10% larger and 50% longer during palpation and exploration than during grooming or passive stimulation. Although activity levels differed between behaviors, the position and spatial extent of the peripheral receptive field was similar over all behaviors that resulted in tactile input. Overall, our data suggest that the 1000–4500 Hz multiunit responses in the Crus IIa GCL of awake rats are correlated with tactile input rather than with movement or any movement parameter and that these responses are likely to be of particular importance during the acquisition of sensory information by perioral structures.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1523/jneurosci.21-10-03549.2001DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6762470PubMed CentralArticle
Additional Information:© 2001 by the Society for Neuroscience. Received Oct. 12, 2000; revised Feb. 16, 2001; accepted Feb. 16, 2001. We are very grateful to Val Mohammadi for performing the histology. This work was helped by conceptual discussions with Christine Chee-Ruiter and Chris Assad, and by technical discussions with Brian Rasnow, David Kewley, and Gary Lorden. Carolyn Chan, Kevin Neville, and Angela Poole helped in many of the behavioral recordings.
Subject Keywords:cerebellar granule cells; mossy fibers; somatosensory; ingestive; grooming; exploration; whiskers; vibrissae; passive touch; active touch; active sensing
Issue or Number:10
PubMed Central ID:PMC6762470
Record Number:CaltechAUTHORS:20191009-081040948
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20191009-081040948
Official Citation:Tactile Responses in the Granule Cell Layer of Cerebellar Folium Crus IIa of Freely Behaving Rats. Mitra J. Hartmann, James M. Bower. Journal of Neuroscience 15 May 2001, 21 (10) 3549-3563; DOI: 10.1523/JNEUROSCI.21-10-03549.2001
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:99175
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:09 Oct 2019 16:13
Last Modified:09 Oct 2019 16:13

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