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The human body at cellular resolution: the NIH Human Biomolecular Atlas Program

Snyder, Michael P. and Cai, Long and Shendure, Jay and Trapnell, Cole and Lin, Shin and Jackson, Dana and Yuan, Guo-Cheng and Zhu, Qian and Dries, Ruben (2019) The human body at cellular resolution: the NIH Human Biomolecular Atlas Program. Nature, 574 (7777). pp. 187-192. ISSN 0028-0836. https://resolver.caltech.edu/CaltechAUTHORS:20191009-112519199

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Abstract

Transformative technologies are enabling the construction of three-dimensional maps of tissues with unprecedented spatial and molecular resolution. Over the next seven years, the NIH Common Fund Human Biomolecular Atlas Program (HuBMAP) intends to develop a widely accessible framework for comprehensively mapping the human body at single-cell resolution by supporting technology development, data acquisition, and detailed spatial mapping. HuBMAP will integrate its efforts with other funding agencies, programs, consortia, and the biomedical research community at large towards the shared vision of a comprehensive, accessible three-dimensional molecular and cellular atlas of the human body, in health and under various disease conditions.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1038/s41586-019-1629-xDOIArticle
ORCID:
AuthorORCID
Cai, Long0000-0002-7154-5361
Yuan, Guo-Cheng0000-0002-2283-4714
Additional Information:© 2019 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. This research is supported by the NIH Common Fund, through the Office of Strategic Coordination/Office of the NIH Director under awards OT2OD026663, OT2OD026671, OT2OD026673, OT2OD026675, OT2OD026677, OT2OD026682, U54AI142766, U54DK120058, U54HG010426, U54HL145608, U54HL145611, UG3HL145593, UG3HL145600, UG3HL145609, and UG3HL145623. Author Contributions: M.P.S., S.L., A.L.P., M.A.A, J.R., O.R.-R., A.H., R.S., N.G., J.S., J.L., P.H., N.A.N., J.C.S., Z.B.-J., K.Z., K.B., Y.L., R.C., D.P., A.L.R., A.P., M.B., and Z.S.G. wrote the manuscript; A.R. and L.G. generated the figures and reviewed and/or edited the manuscript; J.R., O.R.-R., A.H., R.S., N.G., J.S., J.L., P.H., N.A.N., J.C.S., Z.B.-J., K.Z., K.B., Y.L., R.C., D.P., A.L.R., A.P., M.B., and Z.S.G. contributed to discussion and provided critical review and/or revision of the manuscript. All other co-authors outside the writing group reviewed the manuscript and approved of its submission for publication. Contacts of principal investigators for respective TMCs, TTDs, or HIVE are listed first in each section. Competing interests: M.P.S. is a cofounder and on the scientific advisory board of Personalis, Filtircine, SensOmics, Qbio, January, Mirvie, Oralome and Proteus. He is also on the scientific advisory board (SAB) of Genapsys and Jupiter and on the advisory board of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). P.V.K. serves on the SAB to Celsius Therapeutics. A.R. is a member of the SAB of ThermoFisher Scientific and Syros Pharmaceuticals and a founder and an equity holder of Celsius Therapeutics. A.R. holds various patents and has patent filings in the areas of single-cell and spatial genomic technologies, and is a member of the advisory council of the National Human Genome Research Institute (NHGRI). C.K. is a co-founder of Ocean Genomics. P.Y. is a co-founder, paid consultant, director, and equity holder of Ultivue and NuProbe Global and holds several patent filings in the areas of single-cell and spatial genomic technologies. N.G. is a co-founder and equity owner of Datavisyn. R.F.M. is a cofounder and board member of Quantitative Medicine and is on the Advisory Board of Predictive Oncology and the Scientific Advisory Board of the Morgridge Institute for Research. The other authors declare no competing interests.
Funders:
Funding AgencyGrant Number
NIHOT2OD026663
NIHOT2OD026671
NIHOT2OD026673
NIHOT2OD026675
NIHOT2OD026677
NIHOT2OD026682
NIHU54AI142766
NIHU54DK120058
NIHU54HG010426
NIHU54HL145608
NIHU54HL145611
NIHUG3HL145593
NIHUG3HL145600
NIHUG3HL145609
NIHUG3HL145623
Issue or Number:7777
Record Number:CaltechAUTHORS:20191009-112519199
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20191009-112519199
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:99191
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:09 Oct 2019 18:36
Last Modified:09 Oct 2019 18:36

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