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Feedback Regulation of the Heat Shock Response in E. coli

El-Samad, Hana and Khammash, Mustafa and Kurata, Hiroyuki and Doyle, John C. (2003) Feedback Regulation of the Heat Shock Response in E. coli. In: Multidisciplinary Research in Control. Lecture Notes in Control and Information Sciences. No.289. Springer , Berlin, pp. 115-128. ISBN 978-3-540-00917-7.

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Systems Biology is an emerging new field defined as the study of biology as an integrated system of components that act interdependently to accomplish certain functions. This approach holds the promise of offering precious insight into aspects of biological organization that cannot be identified through a reductionist approach concerned solely with the study of individual molecules. In this work, we illustrate this viewpoint through the example of the bacterial heat shock response. The heat shock response is an important mechanism that combats harmful effects of an unmediated increase in temperature. Such an increase in temperature causes the unfolding or aggregation of the cellular proteins, which imposes a tremendous amount of stress on the cell. The heat shock response is implemented through an elaborate system of controls whose purpose is to refold denatured proteins, therefore restoring their normal function. In this paper, we present a deterministic model for the heat shock response. We use this model to gain insight into the design and performance objectives of this response. We then provide a stochastic treatment based on the Stochastic Simulation Algorithm of Gillepsie [18]. This stochastic investigation validates the use of the deterministic approach in modeling the heat shock response, and motivates the investigation of feedback structures that play a role in attenuating stochastic fluctuations.

Item Type:Book Section
Related URLs:
URLURL TypeDescription
El-Samad, Hana0000-0001-6239-9916
Kurata, Hiroyuki0000-0003-4254-2214
Doyle, John C.0000-0002-1828-2486
Additional Information:© 2003 Springer-Verlag Berlin Heidelberg.
Subject Keywords:Heat Shock; Heat Shock Protein; Master Equation; Heat Shock Response; Heat Shock Gene
Series Name:Lecture Notes in Control and Information Sciences
Issue or Number:289
Record Number:CaltechAUTHORS:20191009-114846374
Persistent URL:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:99192
Deposited By: Tony Diaz
Deposited On:09 Oct 2019 19:07
Last Modified:16 Nov 2021 17:44

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