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Human Antibody Genes: Evolutionary and Molecular Genetic Perspectives

Ellison, Jay W. and Hood, Leroy E. (1983) Human Antibody Genes: Evolutionary and Molecular Genetic Perspectives. In: Advances in Human Genetics. Advances in Human Genetics. No.13. Springer , Boston, MA, pp. 113-147. ISBN 978-1-4615-8344-8.

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During the past several years a vast amount of information has been accumulated regarding the genes encoding immunoglobulin (Ig) molecules. Studies in the murine system have shown that the expression of these genes in lymphocytes involves a number of genetic processes, including DNA rearrangements, alternative patterns of RNA splicing, and somatic mutation, all of which serve to amplify the information encoded in the germ line. The cloning of mouse Ig genes has been facilitated by the availability of inducible myeloma tumors, which produce large quantities of homogeneous immunoglobulins (Potter, 1972). These myeloma tumors represent clonal cell populations that have undergone the DNA rearrangements necessary for antibody gene expression, and have furnished large amounts of Ig mRNA, which has served as the starting material for the isolation of the corresponding genes.

Item Type:Book Section
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Hood, Leroy E.0000-0001-7158-3678
Additional Information:© 1983 Plenum Press, New York. We thank Bernita Larsh and Connie Katz for the preparation of the manuscript, and Ellen Kraig and Roger Perlmutter for their comments. This work was supported by a grant from the National Institutes of Health and by a National Research Award (1 T32 GM07616) to one of the authors (JE) from the National Institute of General Medical Sciences.
Funding AgencyGrant Number
NIH Predoctoral Fellowship1 T32 GM07616
National Institute of General Medical SciencesUNSPECIFIED
Subject Keywords:Gene Segment; Human Immunoglobulin; Immunoglobulin Heavy Chain; Antibody Gene; Unequal Crossover
Series Name:Advances in Human Genetics
Issue or Number:13
Record Number:CaltechAUTHORS:20191011-074306600
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:99232
Deposited By: Tony Diaz
Deposited On:11 Oct 2019 17:02
Last Modified:16 Nov 2021 17:44

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