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Eye Position Signal Modulates a Human Parietal Pointing Region during Memory-Guided Movements

DeSouza, Joseph F. X. and Dukelow, Sean P. and Gati, Joseph S. and Menon, Ravi S. and Andersen, Richard A. and Vilis, Tutis (2000) Eye Position Signal Modulates a Human Parietal Pointing Region during Memory-Guided Movements. Journal of Neuroscience, 20 (15). pp. 5835-5840. ISSN 0270-6474. PMCID PMC6772534. https://resolver.caltech.edu/CaltechAUTHORS:20191014-143611942

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Abstract

Using functional magnetic resonance imaging, we examined the signal in parietal regions that were selectively activated during delayed pointing to flashed visual targets and determined whether this signal was dependent on the fixation position of the eyes. Delayed pointing activated a bilateral parietal area in the intraparietal sulcus (rIPS), rostral/anterior to areas activated by saccades. During right-hand pointing to centrally located targets, the left rIPS region showed a significant increase in activation when the eye position was rightward compared with leftward. As expected, activation in motor cortex showed no modulation when only eye position changed. During pointing to retinotopically identical targets, the left rIPS region again showed a significant increased signal when the eye position was rightward compared with leftward. Conversely, when pointing with the left arm, the right rIPS showed an increase in signal when eye position was leftward compared with rightward. The results suggest that the human parietal hand/arm movement region (rIPS), like monkey parietal areas (Andersen et al., 1985), exhibits an eye position modulation of its activity; modulation that may be used to transform the coordinates of the retinotopically coded target position into a motor error command appropriate for the wrist.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1523/jneurosci.20-15-05835.2000DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772534PubMed CentralArticle
ORCID:
AuthorORCID
Andersen, Richard A.0000-0002-7947-0472
Additional Information:© 2000 Society for Neuroscience. Received Nov. 18, 1999; revised May 15, 2000; accepted May 15, 2000. This research was supported by the Medical Research Council of Canada and Human Frontiers in Science. J.F.X.D. was supported by National Sciences and Engineering Council of Canada and Medical Research Council of Canada. We thank L. Van Cleeff and Jason Connolly for assistance during data collection, L. Van Cleeff for the design and construction of equipment, and Jody Culham and Douglas Tweed for invaluable feedback.
Funders:
Funding AgencyGrant Number
Medical Research Council of CanadaUNSPECIFIED
Human Frontier Science ProgramUNSPECIFIED
Natural Sciences and Engineering Research Council of Canada (NSERC)UNSPECIFIED
Subject Keywords:eye position; extraretinal signal; position modulation; spatial transformation; pointing; memory-guided; parietal cortex; intraparietal sulcus; IPS; functional magnetic resonance imaging; fMRI; human
Issue or Number:15
PubMed Central ID:PMC6772534
Record Number:CaltechAUTHORS:20191014-143611942
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20191014-143611942
Official Citation:Eye Position Signal Modulates a Human Parietal Pointing Region during Memory-Guided Movements. Joseph F. X. DeSouza, Sean P. Dukelow, Joseph S. Gati, Ravi S. Menon, Richard A. Andersen, Tutis Vilis. Journal of Neuroscience 1 August 2000, 20 (15) 5835-5840; DOI: 10.1523/JNEUROSCI.20-15-05835.2000
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:99261
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:14 Oct 2019 21:50
Last Modified:14 Oct 2019 21:50

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