Shin, Jong-Shik and Pierce, Niles A. (2006) Nanoscale Molecular Transport by Synthetic DNA Machines. In: Nanotechnology: Science and Computation. Natural Computing Series. Springer , Berlin, pp. 175-188. ISBN 978-3-540-30295-7. https://resolver.caltech.edu/CaltechAUTHORS:20191015-134801443
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Abstract
Biological systems have evolved motor proteins programmed to perform intracellular transport powered by ATP hydrolysis [23, 14]. Striding along a microtubule with a hand-over-hand gait and a step size of ≈8 nm [26], kinesin is capable of taking ≈100 steps per second, typically negotiating ≈100 steps before falling off the microtubule [4]. Replicating these performance characteristics with a synthetic mimic presents a daunting challenge to molecular engineers pursuing programmable active transport as a means to assembling or probing nanoscale systems.
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| Additional Information: | © 2006 Springer-Verlag Berlin Heidelberg. This work was supported by DARPA and the Air Force Research Laboratory, the Ralph M. Parsons Foundation, the Charles Lee Powell Foundation, and the Caltech Center for Biological Circuit Design. | ||||||||||||
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| Subject Keywords: | Apparent Rate Constant; Walker Movement; Periodic Track; Wavelength Pair; Cargo Transport | ||||||||||||
| Series Name: | Natural Computing Series | ||||||||||||
| DOI: | 10.1007/3-540-30296-4_11 | ||||||||||||
| Record Number: | CaltechAUTHORS:20191015-134801443 | ||||||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20191015-134801443 | ||||||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||
| ID Code: | 99277 | ||||||||||||
| Collection: | CaltechAUTHORS | ||||||||||||
| Deposited By: | Tony Diaz | ||||||||||||
| Deposited On: | 15 Oct 2019 22:38 | ||||||||||||
| Last Modified: | 16 Nov 2021 17:45 |
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