Popielarski, Stephen R. and Mishra, Swaroop and Davis, Mark E. (2002) The Effects of Structure on Gene Delivery with Linear β- and γ-Cyclodextrin-Containing Polycations. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 44 (1/4). pp. 453-457. ISSN 0923-0750. doi:10.1023/a:1023084322759. https://resolver.caltech.edu/CaltechAUTHORS:20191015-143301005
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Abstract
Cyclodextrin (CD)-containing polycations are prepared bycopolymerization of3^A3^B-dideoxy-3^A,3^B-diamino-β- and γ-CDs with dimethyl suberimidate·2HCl to yieldpolyamidine products. Both alkyl- and alkoxy-diamines are used to vary the spacing between the CDand the amidine charge centers. It is found that the transfection efficiency andtoxicity of such polycations is dramatically affected by the structure of the spacer separatingthe CD ring from the charge centers and less so by the type of CD used.
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| Additional Information: | © 2002 Kluwer Academic Publishers. Received: 7 May 2002; in final form: 1 October 2002. S.R.P. thanks the Department of Defense for an NDSEG fellowship. We would also like to thank Insert Therapeutics Inc. for partial support of this project. M.E.D. is a consultant to and has financial interest in Insert Therapeutics Inc. | |||||||||
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| Subject Keywords: | cyclodextrin diamines; polymerisation; toxicity; transfection efficiency | |||||||||
| Issue or Number: | 1/4 | |||||||||
| DOI: | 10.1023/a:1023084322759 | |||||||||
| Record Number: | CaltechAUTHORS:20191015-143301005 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20191015-143301005 | |||||||||
| Official Citation: | Popielarski, S.R., Mishra, S. & Davis, M.E. Journal of Inclusion Phenomena (2002) 44: 453. https://doi.org/10.1023/A:1023084322759 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 99281 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Tony Diaz | |||||||||
| Deposited On: | 15 Oct 2019 22:40 | |||||||||
| Last Modified: | 16 Nov 2021 17:45 |
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