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The Effects of Structure on Gene Delivery with Linear β- and γ-Cyclodextrin-Containing Polycations

Popielarski, Stephen R. and Mishra, Swaroop and Davis, Mark E. (2002) The Effects of Structure on Gene Delivery with Linear β- and γ-Cyclodextrin-Containing Polycations. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 44 (1/4). pp. 453-457. ISSN 0923-0750. doi:10.1023/a:1023084322759. https://resolver.caltech.edu/CaltechAUTHORS:20191015-143301005

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Abstract

Cyclodextrin (CD)-containing polycations are prepared bycopolymerization of3^A3^B-dideoxy-3^A,3^B-diamino-β- and γ-CDs with dimethyl suberimidate·2HCl to yieldpolyamidine products. Both alkyl- and alkoxy-diamines are used to vary the spacing between the CDand the amidine charge centers. It is found that the transfection efficiency andtoxicity of such polycations is dramatically affected by the structure of the spacer separatingthe CD ring from the charge centers and less so by the type of CD used.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1023/a:1023084322759DOIArticle
https://rdcu.be/bUnjMPublisherFree ReadCube access
ORCID:
AuthorORCID
Mishra, Swaroop0000-0002-2665-5385
Davis, Mark E.0000-0001-8294-1477
Additional Information:© 2002 Kluwer Academic Publishers. Received: 7 May 2002; in final form: 1 October 2002. S.R.P. thanks the Department of Defense for an NDSEG fellowship. We would also like to thank Insert Therapeutics Inc. for partial support of this project. M.E.D. is a consultant to and has financial interest in Insert Therapeutics Inc.
Funders:
Funding AgencyGrant Number
National Defense Science and Engineering Graduate (NDSEG) FellowshipUNSPECIFIED
Subject Keywords:cyclodextrin diamines; polymerisation; toxicity; transfection efficiency
Issue or Number:1/4
DOI:10.1023/a:1023084322759
Record Number:CaltechAUTHORS:20191015-143301005
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20191015-143301005
Official Citation:Popielarski, S.R., Mishra, S. & Davis, M.E. Journal of Inclusion Phenomena (2002) 44: 453. https://doi.org/10.1023/A:1023084322759
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:99281
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:15 Oct 2019 22:40
Last Modified:16 Nov 2021 17:45

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