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Synthesis of Sulfatide by Cultured Rat Schwann Cells

Fryxell, Karl J. (1980) Synthesis of Sulfatide by Cultured Rat Schwann Cells. Journal of Neurochemistry, 35 (6). pp. 1461-1464. ISSN 0022-3042. doi:10.1111/j.1471-4159.1980.tb09026.x.

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The ^(35)S sulfolipids synthesized by purified cultures of rat Schwann cells, fibroblasts, and a rat cell line (RN2) were studied. Schwann cell 35S sulfolipids were almost entirely [^(35)S]sulfatide, as shown by TLC in two different solvent systems with unlabeled authentic sulfatide run in the same track. RN2 and fibroblasts did not synthesize significant amounts of sulfatide, by the same criteria. Previous studies failed to detect any characteristic myelin components, including sulfatide, on Schwann cells after several days in culture (Brockes et al., 1980a; Mirsky et at., 1980). My results show that Schwann cells continue to synthesize some sulfatide in the absence of neurons.

Item Type:Article
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Additional Information:© 1980 Wiley. Received February 14, 1980; accepted June 9, 1980.
Subject Keywords:Sulfatide; Schwann cells; Sulfolipids
Issue or Number:6
Record Number:CaltechAUTHORS:20191016-084138362
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Official Citation:Fryxell, K. J. (1980), Synthesis of Sulfatide by Cultured Rat Schwann Cells. Journal of Neurochemistry, 35: 1461-1464. doi:10.1111/j.1471-4159.1980.tb09026.x
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:99289
Deposited By: Tony Diaz
Deposited On:16 Oct 2019 21:14
Last Modified:16 Nov 2021 17:45

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