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Flexible recruitment of memory-based choice representations by human medial-frontal cortex

Minxha, Juri and Adolphs, Ralph and Fusi, Stefano and Mamelak, Adam N. and Rutishauser, Ueli (2020) Flexible recruitment of memory-based choice representations by human medial-frontal cortex. Science, 368 (6498). Art. No. eaba3313. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20191022-151855686

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Abstract

Flexibly switching between different tasks is a fundamental human cognitive ability that allows us to make selective use of only the information needed for a given decision. Minxha et al. used single-neuron recordings from patients to understand how the human brain retrieves memories on demand when needed for making a decision and how retrieved memories are dynamically routed in the brain from the temporal to the frontal lobe. When memory was not needed, only medial frontal cortex neural activity was correlated with the task. However, when outcome choices required memory retrieval, frontal cortex neurons were phase-locked to field potentials recorded in the medial temporal lobe. Therefore, depending on demands of the task, neurons in different regions can flexibly engage and disengage their activity patterns.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1126/science.aba3313DOIArticle
https://science.sciencemag.org/content/368/6498/eaba3313/suppl/DC1PublisherSupplementary Materials
https://doi.org/10.1101/809673DOIDiscussion Paper
ORCID:
AuthorORCID
Minxha, Juri0000-0003-4942-3269
Adolphs, Ralph0000-0002-8053-9692
Fusi, Stefano0000-0002-3035-6652
Mamelak, Adam N.0000-0002-4245-6431
Rutishauser, Ueli0000-0002-9207-7069
Additional Information:© 2020 American Association for the Advancement of Science. This is an article distributed under the terms of the Science Journals Default License. Received 25 November 2019; accepted 4 May 2020. We thank the members of the Adolphs and Rutishauser labs for discussion, Columbia Theory Center members F. Stefanini and M. Rigotti for sharing their population decoding analysis expertise, and the staff and J. M. Chung and C. M. Reed of the Cedars-Sinai Epilepsy Monitoring unit for their support. We thank all subjects and their families for their participation. Funding: This work was supported by NIMH (R01MH110831 to U.R.), the BRAIN initiative through the NIH Office of the Director (U01NS103792 to U.R.), the Caltech NIMH Conte Center (P50MH094258 to R.A. and U.R.), the National Science Foundation (CAREER Award BCS-1554105 to U.R. and NeuroNex Program award DBI-1707398 to S.F.), a Memory and Cognitive Disorders Award from the McKnight Foundation for Neuroscience (to U.R.), and the Simons Foundation Collaboration on the Global Brain (542941 to R.A. and PG007079 to S.F.). Author contributions: J.M., U.R., and R.A. designed the study. J.M. performed the experiments. J.M., S.F., and U.R. analyzed the data. J.M., U.R., R.A., and S.F. wrote the paper. A.N.M. performed surgery and supervised clinical work. Competing interests: None. Data and materials availability: Data needed to reproduce results (firing rates of all neurons versus time, precomputed phase-coherence measures for all neurons) have been deposited at OSF (80).
Funders:
Funding AgencyGrant Number
NIHR01MH110831
NIHU01NS103792
NIHP50MH094258
NSFBCS-1554105
NSFDBI-1707398
McKnight FoundationUNSPECIFIED
Simons Foundation542941
Simons FoundationPG007079
Issue or Number:6498
Record Number:CaltechAUTHORS:20191022-151855686
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20191022-151855686
Official Citation:Flexible recruitment of memory-based choice representations by the human medial frontal cortex. BY JURI MINXHA, RALPH ADOLPHS, STEFANO FUSI, ADAM N. MAMELAK, UELI RUTISHAUSER. SCIENCE 26 JUN 2020, 368/6498: eaba3313; doi: 10.1126/science.aba3313
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:99397
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:22 Oct 2019 22:26
Last Modified:26 Jun 2020 17:54

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