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Evaluation of algorithms for correction of transcranial magnetic stimulation-induced artifacts in electroencephalograms

Vafidis, Pantelis and Kimiskidis, Vasilios K. and Kugiumtzis, Dimitris (2019) Evaluation of algorithms for correction of transcranial magnetic stimulation-induced artifacts in electroencephalograms. Medical and Biological Engineering and Computing, 57 (12). pp. 2599-2615. ISSN 0140-0118. https://resolver.caltech.edu/CaltechAUTHORS:20191028-142555885

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Abstract

Transcranial magnetic stimulation combined with electroencephalography (TMS-EEG) is widely used to study the reactivity and connectivity of brain regions for clinical or research purposes. The electromagnetic pulse of the TMS device generates at the instant of administration an artifact of large amplitude and a duration up to tens of milliseconds that overlaps with brain activity. Methods for TMS artifact correction have been developed to remove the artifact and recover the underlying, immediate response of the cerebral cortex to the magnetic stimulus. In this study, four such algorithms are evaluated. Since there is no ground truth for the masked brain activity, pilot data formed from the superposition of the isolated TMS artifact on EEG brain activity are used to evaluate the performance of the algorithms. Different scenarios of TMS-EEG experiments are considered for the evaluation: TMS at resting state, TMS inducing epileptiform discharges, and TMS administered during epileptiform discharges. We show that a proposed gap filling method is able to reproduce qualitative characteristics and, in many cases, closely resemble the hidden EEG signal. Finally, shortcomings of the TMS correction algorithms as well as the pilot data approach are discussed.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1007/s11517-019-02053-3DOIArticle
ORCID:
AuthorORCID
Kugiumtzis, Dimitris0000-0002-5337-5688
Additional Information:© 2019 International Federation for Medical and Biological Engineering. Received 23 March 2019; Accepted 27 September 2019; First Online 26 October 2019. The authors would like to thank the patient for participating in the study. The authors declare that they have no conflict of interest. Ethical approval: All procedures performed involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments. Informed consent was obtained from all individual participants included in the study.
Subject Keywords:Transcranial magnetic stimulation; Electroencephalography; Artifact correction; Delay embedding
Issue or Number:12
Record Number:CaltechAUTHORS:20191028-142555885
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20191028-142555885
Official Citation:Vafidis, P., Kimiskidis, V.K. & Kugiumtzis, D. Evaluation of algorithms for correction of transcranial magnetic stimulation-induced artifacts in electroencephalograms. Med Biol Eng Comput 57, 2599–2615 (2019) doi:10.1007/s11517-019-02053-3
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:99496
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:28 Oct 2019 21:40
Last Modified:10 Dec 2019 22:15

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