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Role of Synaptic and Voltage-Gated Currents in the Control of Purkinje Cell Spiking: A Modeling Study

Jaeger, Dieter and De Schutter, Erik and Bower, James M. (1997) Role of Synaptic and Voltage-Gated Currents in the Control of Purkinje Cell Spiking: A Modeling Study. Journal of Neuroscience, 17 (1). pp. 91-106. ISSN 0270-6474. PMCID PMC6793698. https://resolver.caltech.edu/CaltechAUTHORS:20191030-150138163

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Abstract

We have used a realistic computer model to examine interactions between synaptic and intrinsic voltage-gated currents during somatic spiking in cerebellar Purkinje cells. We have shown previously that this model generates realistic in vivo patterns of somatic spiking in the presence of continuous background excitatory and inhibitory input (De Schutter and Bower, 1994b). In the present study, we analyzed the flow of synaptic and intrinsic currents across the dendritic membrane and the interaction between the soma and dendrite underlying this spiking behavior. This analysis revealed that: (1) dendritic inward current flow was dominated by a noninactivating P-type calcium current, resulting in a continuous level of depolarization; (2) the mean level of this depolarization was controlled by the mean rate of excitatory and inhibitory synaptic input; (3) the synaptic control involved a voltage-clamping mechanism exerted by changes of synaptic driving force at different membrane potentials; (4) the resulting total current through excitatory and inhibitory synapses was near-zero, with a small outward bias opposing the P-type calcium current; (5) overall, the dendrite acted as a variable current sink with respect to the soma, slowing down intrinsic inward currents in the soma; (6) the somato-dendritic current showed important phasic changes during each spike cycle; and (7) the precise timing of somatic spikes was the result of complex interactions between somatic and dendritic currents that did not directly reflect the timing of synaptic input. These modeling results suggest that Purkinje cells act quite differently from simple summation devices, as has been assumed previously in most models of cerebellar function. Specific physiologically testable predictions are discussed.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1523/jneurosci.17-01-00091.1997DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6793698PubMed CentralArticle
Additional Information:© 1996 Society for Neuroscience. Received June 6, 1996; revised Sept. 19, 1996; accepted Oct. 2, 1996. This work was supported by the Human Frontiers Science Program, the Sloan Foundation, and National Institute of Neurological Disorders and Stroke NS-31378.
Funders:
Funding AgencyGrant Number
Human Frontier Science ProgramUNSPECIFIED
Alfred P. Sloan FoundationUNSPECIFIED
NIHNS-31378
National Institute of Neurological Disorders and Stroke (NINDS)UNSPECIFIED
Subject Keywords:cerebellum; coding; dendrite; spiking; inhibition; synapse; balance; model; simulation; genesis
Issue or Number:1
PubMed Central ID:PMC6793698
Record Number:CaltechAUTHORS:20191030-150138163
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20191030-150138163
Official Citation:The Role of Synaptic and Voltage-Gated Currents in the Control of Purkinje Cell Spiking: A Modeling Study. Dieter Jaeger, Erik De Schutter, James M. Bower. Journal of Neuroscience 1 January 1997, 17 (1) 91-106; DOI: 10.1523/JNEUROSCI.17-01-00091.1997
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:99565
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:30 Oct 2019 22:11
Last Modified:30 Oct 2019 22:11

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