A 512-Pixel, 51-kHz-Frame-Rate, Dual-Shank, Lens-Less, Filter-Less Single-Photon Avalanche Diode CMOS Neural Imaging Probe

Choi, Jaebin and Taal, Adriaan J. and Pollmann, Eric H. and Lee, Changhyuk and Kim, Kukjoo and Moreaux, Laurent C. and Roukes, Michael L. and Shepard, Kenneth L. (2019) A 512-Pixel, 51-kHz-Frame-Rate, Dual-Shank, Lens-Less, Filter-Less Single-Photon Avalanche Diode CMOS Neural Imaging Probe. IEEE Journal of Solid-State Circuits, 54 (11). pp. 2957-2968. ISSN 0018-9200. doi:10.1109/jssc.2019.2941529. https://resolver.caltech.edu/CaltechAUTHORS:20191031-124926910

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Abstract

We present an implantable single-photon shank-based imager, monolithically integrated onto a single CMOS IC. The imager comprises of 512 single-photon avalanche diodes distributed along two shanks, with a 6-bit depth in-pixel memory and an on-chip digital-to-time converter. To scale down the system to a minimally invasive form factor, we substitute optical filtering and focusing elements with a time-gated, angle-sensitive detection system. The imager computationally reconstructs the position of fluorescent sources within a 3-D volume of 3.4 mm × 600 μm× 400 μm .

Item Type:

Article

Related URLs:

URL	URL Type	Description
https://doi.org/10.1109/jssc.2019.2941529	DOI	Article

ORCID:

Author	ORCID
Choi, Jaebin	0000-0002-8348-7701
Taal, Adriaan J.	0000-0002-1649-2826
Lee, Changhyuk	0000-0002-1108-6327
Moreaux, Laurent C.	0000-0003-1276-5062
Roukes, Michael L.	0000-0002-2916-6026
Shepard, Kenneth L.	0000-0003-0665-6775

Additional Information:

© 2019 IEEE. Manuscript received May 14, 2019; revised August 1, 2019; accepted August 28, 2019. Date of current version October 23, 2019. This article was approved by Associate Editor Pedram Mohseni. This work was supported in part by the National Institutes of Health under Grant U01NS090596, in part by the Defense Advanced Research Projects Agency (DARPA) under Contract N66001–17-C-4012, and in part by the U.S. Army Research Laboratory and the U.S. Army Research Office under Contract W911NF-12–1-0594.

Funders:

Funding Agency	Grant Number
NIH	U01NS090596
Defense Advanced Research Projects Agency (DARPA)	N66001-17-C-4012
Army Research Laboratory	UNSPECIFIED
Army Research Office (ARO)	W911NF-12-1-0594

Subject Keywords:

CMOS, compressed sensing, neural probe, single-photon avalanche diode (SPAD), time-gated fluorescence imaging

Issue or Number:

DOI:

10.1109/jssc.2019.2941529

Record Number:

CaltechAUTHORS:20191031-124926910

Persistent URL:

https://resolver.caltech.edu/CaltechAUTHORS:20191031-124926910

Official Citation:

J. Choi et al., "A 512-Pixel, 51-kHz-Frame-Rate, Dual-Shank, Lens-Less, Filter-Less Single-Photon Avalanche Diode CMOS Neural Imaging Probe," in IEEE Journal of Solid-State Circuits, vol. 54, no. 11, pp. 2957-2968, Nov. 2019. doi: 10.1109/JSSC.2019.2941529

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No commercial reproduction, distribution, display or performance rights in this work are provided.

ID Code:

99588

Collection:

CaltechAUTHORS

Deposited By:

George Porter

Deposited On:

31 Oct 2019 21:16

Last Modified:

16 Nov 2021 17:47

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