Choi, Jaebin and Taal, Adriaan J. and Pollmann, Eric H. and Lee, Changhyuk and Kim, Kukjoo and Moreaux, Laurent C. and Roukes, Michael L. and Shepard, Kenneth L. (2019) A 512-Pixel, 51-kHz-Frame-Rate, Dual-Shank, Lens-Less, Filter-Less Single-Photon Avalanche Diode CMOS Neural Imaging Probe. IEEE Journal of Solid-State Circuits, 54 (11). pp. 2957-2968. ISSN 0018-9200. doi:10.1109/jssc.2019.2941529. https://resolver.caltech.edu/CaltechAUTHORS:20191031-124926910
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Abstract
We present an implantable single-photon shank-based imager, monolithically integrated onto a single CMOS IC. The imager comprises of 512 single-photon avalanche diodes distributed along two shanks, with a 6-bit depth in-pixel memory and an on-chip digital-to-time converter. To scale down the system to a minimally invasive form factor, we substitute optical filtering and focusing elements with a time-gated, angle-sensitive detection system. The imager computationally reconstructs the position of fluorescent sources within a 3-D volume of 3.4 mm × 600 μm× 400 μm .
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Additional Information: | © 2019 IEEE. Manuscript received May 14, 2019; revised August 1, 2019; accepted August 28, 2019. Date of current version October 23, 2019. This article was approved by Associate Editor Pedram Mohseni. This work was supported in part by the National Institutes of Health under Grant U01NS090596, in part by the Defense Advanced Research Projects Agency (DARPA) under Contract N66001–17-C-4012, and in part by the U.S. Army Research Laboratory and the U.S. Army Research Office under Contract W911NF-12–1-0594. | ||||||||||||||
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Subject Keywords: | CMOS, compressed sensing, neural probe, single-photon avalanche diode (SPAD), time-gated fluorescence imaging | ||||||||||||||
Issue or Number: | 11 | ||||||||||||||
DOI: | 10.1109/jssc.2019.2941529 | ||||||||||||||
Record Number: | CaltechAUTHORS:20191031-124926910 | ||||||||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20191031-124926910 | ||||||||||||||
Official Citation: | J. Choi et al., "A 512-Pixel, 51-kHz-Frame-Rate, Dual-Shank, Lens-Less, Filter-Less Single-Photon Avalanche Diode CMOS Neural Imaging Probe," in IEEE Journal of Solid-State Circuits, vol. 54, no. 11, pp. 2957-2968, Nov. 2019. doi: 10.1109/JSSC.2019.2941529 | ||||||||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||||
ID Code: | 99588 | ||||||||||||||
Collection: | CaltechAUTHORS | ||||||||||||||
Deposited By: | George Porter | ||||||||||||||
Deposited On: | 31 Oct 2019 21:16 | ||||||||||||||
Last Modified: | 16 Nov 2021 17:47 |
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