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Functional Architecture of Motion Direction in the Mouse Superior Colliculus

Li, Ya-tang and Turan, Zeynep and Meister, Markus (2020) Functional Architecture of Motion Direction in the Mouse Superior Colliculus. Current Biology, 30 (17). pp. 3304-3315. ISSN 0960-9822. https://resolver.caltech.edu/CaltechAUTHORS:20191031-141639740

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Abstract

Motion vision is important in guiding animal behavior. Both the retina and the visual cortex process object motion in largely unbiased fashion: all directions are represented at all locations in the visual field. We investigate motion processing in the superior colliculus of the awake mouse by optically recording neural responses across both hemispheres. Within the retinotopic map, one finds large regions of ∼500 μm size where neurons prefer the same direction of motion. This preference is maintained in depth to ∼350 μm. The scale of these patches, ∼30 degrees of visual angle, is much coarser than the animal’s visual resolution (∼2 degrees). A global map of motion direction shows approximate symmetry between the left and right hemispheres and a net bias for upward-nasal motion in the upper visual field.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.cub.2020.06.023DOIArticle
https://doi.org/10.1101/825711DOIDiscussion Paper
ORCID:
AuthorORCID
Li, Ya-tang0000-0003-2763-1534
Meister, Markus0000-0003-2136-6506
Additional Information:© 2020 Elsevier Inc. Received 9 December 2019, Revised 12 April 2020, Accepted 5 June 2020, Available online 10 July 2020. M.M. was supported by grants from NIH (R01 NS111477) and from the Simons Foundation (543015SPI). Y.-t.L was supported by a grant from the NEI (K99EY028640) and a Helen Hay Whitney Postdoctoral Fellowship. Author Contributions: Y.-t.L designed the study, performed all experiments, interpreted results, and wrote the manuscript. Z.T. provided partial-cortex mutant mice and validated their brain anatomy. M.M. helped design the study, interpret results, and write the manuscript. The authors declare no competing interests.
Funders:
Funding AgencyGrant Number
NIHR01 NS111477
Simons Foundation543015SPI
NIHK99EY028640
Helen Hay Whitney FoundationUNSPECIFIED
Issue or Number:17
Record Number:CaltechAUTHORS:20191031-141639740
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20191031-141639740
Official Citation:Ya-tang Li, Zeynep Turan, Markus Meister, Functional Architecture of Motion Direction in the Mouse Superior Colliculus, Current Biology, Volume 30, Issue 17, 2020, Pages 3304-3315.e4, ISSN 0960-9822, https://doi.org/10.1016/j.cub.2020.06.023. (http://www.sciencedirect.com/science/article/pii/S0960982220308393)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:99595
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:31 Oct 2019 21:39
Last Modified:21 Sep 2020 20:24

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