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Identification of a forebrain motor programming network for the learned song of zebra finches

Vu, Eric T. and Mazurek, Mark E. and Kuo, Yu-Chien (1994) Identification of a forebrain motor programming network for the learned song of zebra finches. Journal of Neuroscience, 14 (11). pp. 6924-6934. ISSN 0270-6474. PMCID PMC6577280. https://resolver.caltech.edu/CaltechAUTHORS:20191101-110537021

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Abstract

The stereotyped delivery of sequences of vocalizations by singing zebra finches is thought to be mediated by a “central motor program.” We hypothesized that electrically stimulating, and thus perturbing, the neural components of this motor program during singing should alter the subsequent singing pattern. In contrast, perturbing the activity of other neurons in the song motor pathway that do not participate directly in generating the song temporal pattern should not affect the singing pattern. We found that unilaterally stimulating the forebrain area RA of singing birds with chronically implanted electrodes distorted ongoing syllables without changing the order or timing of ensuing syllables. However, stimulating forebrain area HVc, which projects directly to RA, altered both ongoing syllables and the ensuing song pattern. These findings indicate that syllable sequencing during singing is organized in forebrain areas above RA (including HVc) and that the resulting pattern is imposed on lower structures of the motor pathway. Furthermore, the observation that unilateral forebrain perturbation was sufficient to alter the pattern of this bilaterally organized behavior suggests that (non-auditory) feedback pathways to the forebrain exist to coordinate the two hemispheres during singing. We suggest that the study of the motor control system for birdsong has provided the most direct evidence to date for localizing the programming of a skilled motor sequence to the telencephalon.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1523/jneurosci.14-11-06924.1994DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6577280PubMed CentralArticle
Additional Information:© 1994 Society for Neuroscience. Received Mar. 29, 1994; accepted May 5, 1994. We thank M. Oei for technical assistance, M. Konishi for help with cochlear removal, and D. Perkel, M. Schmidt, A. Doupe, and M. Konishi for discussion. This work was supported by an individual National Research Service Award to E.T.V. and funds from the Bing Behavioral Biology Chair to M. Konishi.
Funders:
Funding AgencyGrant Number
NIHUNSPECIFIED
Bing Behavioral Biology ChairUNSPECIFIED
Subject Keywords:birdsong, song system, central pattern generation, motor control, brain electrical stimulation, motor programming, vocalization, songbird
Issue or Number:11
PubMed Central ID:PMC6577280
Record Number:CaltechAUTHORS:20191101-110537021
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20191101-110537021
Official Citation:Identification of a forebrain motor programming network for the learned song of zebra finches. ET Vu, ME Mazurek, YC Kuo. Journal of Neuroscience 1 November 1994, 14 (11) 6924-6934; DOI: 10.1523/JNEUROSCI.14-11-06924.1994
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:99616
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:01 Nov 2019 18:23
Last Modified:01 Nov 2019 18:23

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