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Synaptic basis for developmental plasticity in a birdsong nucleus

Mooney, Richard (1992) Synaptic basis for developmental plasticity in a birdsong nucleus. Journal of Neuroscience, 12 (7). pp. 2464-2477. ISSN 0270-6474. PMCID PMC6575824; PMC6618629. doi:10.1523/jneurosci.12-07-02464.1992.

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The development and adult production of birdsong are subserved by specialized brain nuclei, including the robust nucleus of the archistriatum (RA), and its afferents originating in the caudal nucleus of the ventral hyperstriatum (HVc) and the lateral portion of the magnocellular nucleus of the anterior neostriatum (L-MAN). An in vitro brain slice preparation was used to characterize the electrophysiological properties of L-MAN and HVc axonal synapses within RA and to examine how these synaptic connections change during the course of song development. Electrical stimulation of L-MAN and not HVc fibers evoked excitatory synaptic potentials from virtually all RA neurons in brain slices prepared from male and female zebra finches less than 25 d of age. These “L-MAN” EPSPs were blocked substantially by the NMDA receptor antagonist D(-)-2-amino-5-phosphonopentanoic acid (D-APV; 50–100 microM) and by hyperpolarization of the postsynaptic membrane. In contrast, when slices were prepared from male finches greater than 35 d of age, electrical stimulation of the L-MAN and the HVc fiber tracts evoked synaptic responses from over 70% of RA neurons. Although the L-MAN EPSPs resembled those seen in RA before day 25, the “HVc” EPSPs were relatively insensitive to D-APV, but almost completely abolished by 6-cyano-7-nitroquinoxaline-2,3-dione, a non-NMDA glutamate receptor antagonist. These experiments indicate that L-MAN and HVc axons make pharmacologically distinct synapses on the same RA neurons, and that these synapses first form at different stages during development.

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Additional Information:© 1992 Society for Neuroscience. Received Sept. 19, 1991; revised Dec. 26, 1991; accepted Jan. 6, 1992. I am especially grateful for the guidance provided by Dr. Mark Konishi, to Gene Akutagawa for technical support, and to Ors. Allison Doupe and Gilles Laurent for critical discussion of the manuscript. The work was made possible by NIH Predoctoral Training Grant 5 T32 GM07737-10, the Lucille B. Markey Charitable Trust, and the McKnight Foundation.
Funding AgencyGrant Number
NIH Predoctoral Fellowship5 T32 GM07737-10
Lucille B. Markey Charitable TrustUNSPECIFIED
McKnight FoundationUNSPECIFIED
Issue or Number:7
PubMed Central ID:PMC6575824; PMC6618629
Record Number:CaltechAUTHORS:20191101-155126565
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Official Citation:Synaptic basis for developmental plasticity in a birdsong nucleus. R Mooney. Journal of Neuroscience 1 July 1992, 12 (7) 2464-2477; DOI: 10.1523/JNEUROSCI.12-07-02464.1992
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:99630
Deposited By: Tony Diaz
Deposited On:01 Nov 2019 23:17
Last Modified:01 Jun 2023 23:49

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