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Aluminum Metasurface with Hybrid Multipolar Plasmons for 1000-Fold Broadband Visible Fluorescence Enhancement and Multiplexed Biosensing

Siddique, Radwanul Hasan and Kumar, Shailabh and Narasimhan, Vinayak and Kwon, Hyonghan and Choo, Hyuck (2019) Aluminum Metasurface with Hybrid Multipolar Plasmons for 1000-Fold Broadband Visible Fluorescence Enhancement and Multiplexed Biosensing. ACS Nano, 13 (12). pp. 13775-13783. ISSN 1936-0851. doi:10.1021/acsnano.9b02926.

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Aluminum (Al)-based nanoantennae traditionally suffer from weak plasmonic performance in the visible range, necessitating the application of more expensive noble metal substrates for rapidly expanding biosensing opportunities. We introduce a metasurface comprising Al nanoantennae of nanodisks-in-cavities that generate hybrid multipolar lossless plasmonic modes to strongly enhance local electromagnetic fields and increase the coupled emitter’s local density of states throughout the visible regime. This results in highly efficient electromagnetic field confinement in visible wavelengths by these nanoantennae, favoring real-world plasmonic applications of Al over other noble metals. Additionally, we demonstrate spontaneous localization and concentration of target molecules at metasurface hotspots, leading to further improved on-chip detection sensitivity and a broadband fluorescence-enhancement factor above 1000 for visible wavelengths with respect to glass chips commonly used in bioassays. Using the metasurface and a multiplexing technique involving three visible wavelengths, we successfully detected three biomarkers, insulin, vascular endothelial growth factor, and thrombin relevant to diabetes, ocular and cardiovascular diseases, respectively, in a single 10 μL droplet containing only 1 fmol of each biomarker.

Item Type:Article
Related URLs:
URLURL TypeDescription
Siddique, Radwanul Hasan0000-0001-7494-5857
Kumar, Shailabh0000-0001-5383-3282
Narasimhan, Vinayak0000-0003-4165-402X
Choo, Hyuck0000-0002-8903-7939
Additional Information:© 2019 American Chemical Society. Received: April 15, 2019; Accepted: November 5, 2019; Published: November 5, 2019. We gratefully acknowledge critical support and infrastructure provided for this work by the Kavli Nanoscience Institute at Caltech. We thank Haeri Park for fruitful discussion on the manuscript. Imaging was performed in the Biological Imaging Facility, with the support of the Caltech Beckman Institute and the Arnold and Mabel Beckman Foundation. The research was funded by a Samsung Global Research Outreach program. Author Contributions: These authors contributed equally to this work. R.H.S. and S.K. conceived the idea and equally contributed in the study. R.H.S. and S.K. designed the analyses, performed the experiments. H.C. provided supervision to R.H.S. and S.K. H.K. and V.N. assisted in the simulation process. R.H.S., S.K., and H.C. wrote the manuscript. All authors discussed the results and commented on the manuscript. The authors declare no competing financial interest.
Group:Kavli Nanoscience Institute
Funding AgencyGrant Number
Kavli Nanoscience InstituteUNSPECIFIED
Caltech Beckman InstituteUNSPECIFIED
Arnold and Mabel Beckman FoundationUNSPECIFIED
SAMSUNG Global Research OutreachUNSPECIFIED
Subject Keywords:nanoplasmonics, scalable metasurface, aluminum plasmonics, strong light-matter interaction, fluorescence enhancement, multiplexed biosensing
Issue or Number:12
Record Number:CaltechAUTHORS:20191105-142631620
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Official Citation:Aluminum Metasurface with Hybrid Multipolar Plasmons for 1000-Fold Broadband Visible Fluorescence Enhancement and Multiplexed Biosensing. Radwanul Hasan Siddique, Shailabh Kumar, Vinayak Narasimhan, Hyounghan Kwon, and Hyuck Choo. ACS Nano 2019 13 (12), 13775-13783. DOI: 10.1021/acsnano.9b02926
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:99679
Deposited By: Tony Diaz
Deposited On:05 Nov 2019 22:33
Last Modified:16 Nov 2021 17:48

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