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Network architecture and regulatory logic in neural crest development

Hovland, Austin S. and Rothstein, Megan and Simoes‐Costa, Marcos (2020) Network architecture and regulatory logic in neural crest development. Wiley Interdisciplinary Reviews. Systems Biology and Medicine, 12 (2). Art. No. e1468. ISSN 1939-5094. https://resolver.caltech.edu/CaltechAUTHORS:20191111-083215066

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Abstract

The neural crest is an ectodermal cell population that gives rise to over 30 cell types during vertebrate embryogenesis. These stem cells are formed at the border of the developing central nervous system and undergo extensive migration before differentiating into components of multiple tissues and organs. Neural crest formation and differentiation is a multistep process, as these cells transition through sequential regulatory states before adopting their adult phenotype. Such changes are governed by a complex gene regulatory network (GRN) that integrates environmental and cell‐intrinsic inputs to regulate cell identity. Studies of neural crest cells in a variety of vertebrate models have elucidated the function and regulation of dozens of the molecular players that are part of this network. The neural crest GRN has served as a platform to explore the molecular control of multipotency, cell differentiation, and the evolution of vertebrates. In this review, we employ this genetic program as a stepping‐stone to explore the architecture and the regulatory principles of developmental GRNs. We also discuss how modern genomic approaches can further expand our understanding of genetic networks in this system and others.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1002/wsbm.1468DOIArticle
ORCID:
AuthorORCID
Hovland, Austin S.0000-0002-7590-734X
Simoes‐Costa, Marcos0000-0003-1452-7068
Additional Information:© 2019 Wiley Periodicals, Inc. Issue Online: 06 February 2020; Version of Record online: 08 November 2019; Manuscript accepted: 11 October 2019; Manuscript revised: 25 September 2019; Manuscript received: 02 May 2019. Funding Information: Basil O'Connor Starter Scholar Award. Grant Number: to M.S.‐C. Center for Scientific Review. Grant Numbers: R00DE024232, T32HD057854. National Institutes of Health. Grant Numbers: R00DE024232, T32HD057854.
Funders:
Funding AgencyGrant Number
Basil O'Connor Starter Scholar AwardUNSPECIFIED
NIHR00DE024232
NIH Predoctoral FellowshipT32HD057854
Subject Keywords:cell differentiation; circuits; gene regulatory network; neural crest cells; stem cells
Issue or Number:2
Record Number:CaltechAUTHORS:20191111-083215066
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20191111-083215066
Official Citation:Hovland, AS, Rothstein, M, Simoes‐Costa, M. Network architecture and regulatory logic in neural crest development. WIREs Syst Biol Med. 2020; 12:e1468. https://doi.org/10.1002/wsbm.1468
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:99768
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:12 Nov 2019 23:19
Last Modified:12 Feb 2020 17:39

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