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Era of Digital Health: A Review of Portable and Wearable Affinity Biosensors

Tu, Jiaobing and Torrente-Rodríguez, Rebeca M. and Wang, Minqiang and Gao, Wei (2020) Era of Digital Health: A Review of Portable and Wearable Affinity Biosensors. Advanced Functional Materials, 30 (29). Art. No. 1906713. ISSN 1616-301X. doi:10.1002/adfm.201906713.

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Digital health facilitated by wearable/portable electronics and big data analytics holds great potential in empowering patients with real‐time diagnostics tools and information. The detection of a majority of biomarkers at trace levels in body fluids using mobile health (mHealth) devices requires bioaffinity sensors that rely on “bioreceptors” for specific recognition. Portable point‐of‐care testing (POCT) bioaffinity sensors have demonstrated their broad utility for diverse applications ranging from health monitoring to disease diagnosis and management. In addition, flexible and stretchable electronics‐enabled wearable platforms have emerged in the past decade as an interesting approach in the ambulatory collection of real‐time data. Herein, the technological advancements of mHealth bioaffinity sensors evolved from laboratory assays to portable POCT devices, and to wearable electronics, are synthesized. The involved recognition events in the mHealth affinity biosensors enabled by bioreceptors (e.g., antibodies, DNAs, aptamers, and molecularly imprinted polymers) are discussed along with their transduction mechanisms (e.g., electrochemical and optical) and system‐level integration technologies. Finally, an outlook of the field is provided and key technological bottlenecks to overcome identified, in order to achieve a new sensing paradigm in wearable bioaffinity platforms.

Item Type:Article
Related URLs:
URLURL TypeDescription Image
Tu, Jiaobing0000-0002-7653-6640
Gao, Wei0000-0002-8503-4562
Additional Information:© 2019 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim. Received: August 15, 2019; Revised: September 25, 2019; Published online: November 14, 2019. This work was supported by the Rothenberg Innovation Initiative (RI2) program at California Institute of Technology (Caltech), Caltech—City of Hope Biomedical Research Initiative, the Carver Mead New Adventures Fund, and American Heart Association Grant no. 19TPA34850157 (all to W.G.). J.T. was supported by the National Science Scholarship (NSS) from the Agency of Science Technology and Research (A*STAR) Singapore. The authors declare no conflict of interest.
Funding AgencyGrant Number
Rothenberg Innovation Initiative (RI2)UNSPECIFIED
Caltech-City of Hope Biomedical InitiativeUNSPECIFIED
Carver Mead New Adventures FundUNSPECIFIED
American Heart Association19TPA34850157
Agency for Science, Technology and Research (A*STAR)UNSPECIFIED
Subject Keywords:bioaffinity sensors; digital health; flexible electronics; point‐of‐care testing/diagnostics; wearable sensors
Issue or Number:29
Record Number:CaltechAUTHORS:20191114-105819705
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Official Citation:Tu, J., Torrente‐Rodríguez, R. M., Wang, M., Gao, W., The Era of Digital Health: A Review of Portable and Wearable Affinity Biosensors. Adv. Funct. Mater. 2020, 30, 1906713.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:99837
Deposited By: Tony Diaz
Deposited On:14 Nov 2019 21:25
Last Modified:19 Apr 2023 20:53

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