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Can we use structural knowledge to design a protective vaccine against HIV-1?

Bjorkman, Pamela J. (2020) Can we use structural knowledge to design a protective vaccine against HIV-1? HLA, 95 (2). pp. 95-103. ISSN 2059-2302. doi:10.1111/tan.13759.

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HIV/AIDS remains one of the most important current threats to global public health. Since its identification in the early 1980s, at least 75 million people have been infected with HIV‐1, the virus that causes AIDS. Although anti‐retroviral drugs are effective at prolonging life after infection in the developed world, they are associated with significant side effects and are not in widespread use in the developing world. The best way to control the AIDS epidemic would be a vaccine that protects against infection by HIV‐1. Most vaccines work by inducing antibodies in serum or mucosa that block infection or prevent invasion of the bloodstream. Here I describe background related to my laboratory's attempts to develop an immunogen that would elicit protective antibodies against HIV‐1.

Item Type:Article
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URLURL TypeDescription
Bjorkman, Pamela J.0000-0002-2277-3990
Additional Information:© 2019 Wiley. Issue Online: 01 January 2020; Version of Record online: 27 November 2019; Accepted manuscript online: 12 November 2019; Manuscript accepted: 08 November 2019; Manuscript received: 17 October 2019. Data Availability Statement: Data sharing is not applicable to this article as no new data were created or analyzed in this study. Funding Information: National Institutes of Health. Grant Number: P50 8 P50 AI150464‐13; National Institute of Allergy and Infectious Diseases of the National Institutes of Health. Grant Number: HIVRAD P01 P01AI10014.
Funding AgencyGrant Number
NIHP50 8 P50 AI150464‐13
NIHP01 P01AI10014
Subject Keywords:HIV; HLA
Issue or Number:2
Record Number:CaltechAUTHORS:20191118-073713001
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Official Citation:Bjorkman, PJ. Can we use structural knowledge to design a protective vaccine against HIV‐1? HLA. 2020; 95: 95–103.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:99882
Deposited By: Tony Diaz
Deposited On:18 Nov 2019 16:20
Last Modified:16 Nov 2021 17:49

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