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Published February 10, 2010 | Accepted Version
Journal Article Open

Design and Optimization of Coin-Shaped Microreactor Chips for PET Radiopharmaceutical Synthesis


An integrated elastomeric microfluidic device, with a footprint the size of a postage stamp, has been designed and optimized for multistep radiosynthesis of PET tracers. Methods: The unique architecture of the device is centered around a 5-µL coin-shaped reactor, which yields reaction efficiency and speed from a combination of high reagent concentration, pressurized reactions, and rapid heat and mass transfer. Its novel features facilitate mixing, solvent exchange, and product collection. New mixing mechanisms assisted by vacuum, pressure, and chemical reactions are exploited. Results: The architecture of the reported reactor is the first that has allowed batch-mode microfluidic devices to produce radiopharmaceuticals of sufficient quality and quantity to be validated by in vivo imaging. Conclusion: The reactor has the potential to produce multiple human doses of ^(18)F-FDG; the most impact, however, is expected in the synthesis of PET radiopharmaceuticals that can be made only with low yields by currently available equipment.

Additional Information

© 2010 by the Society of Nuclear Medicine, Inc. Received May 12, 2009; revision accepted Nov. 9, 2009. We acknowledge Carl Meinhart of UC Santa Barbara for theoretic investigations of on-chip processes, which will be published separately. This work was funded by Siemens Molecular Imaging, Biomarker Research, Culver City, California.

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