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Published June 1, 2012 | Accepted Version
Journal Article Open

In Vivo Diagnosis of Melanoma and Nonmelanoma Skin Cancer Using Oblique Incidence Diffuse Reflectance Spectrometry


Early detection and treatment of skin cancer can significantly improve patient outcome. However, present standards for diagnosis require biopsy and histopathologic examinations that are relatively invasive, expensive, and difficult for patients with many early-stage lesions. Here, we show an oblique incidence diffuse reflectance spectroscopic (OIDRS) system that can be used for rapid skin cancer detection in vivo. This system was tested under clinical conditions by obtaining spectra from pigmented and nonpigmented skin lesions, including melanomas, differently staged dysplastic nevi, and common nevi that were validated by standard pathohistologic criteria. For diagnosis of pigmented melanoma, the data obtained achieved 90% sensitivity and specificity for a blinded test set. In a second analysis, we showed that this spectroscopy system can also differentiate nonpigmented basal cell or squamous cell carcinomas from noncancerous skin abnormalities, such as actinic keratoses and seborrheic keratoses, achieving 92% sensitivity and specificity. Taken together, our findings establish how OIDRS can be used to more rapidly and easily diagnose skin cancer in an accurate and automated manner in the clinic.

Additional Information

© 2012 American Association for Cancer Research. Received December 14, 2011; revised March 8, 2012; accepted March 26, 2012; published Online First April 5, 2012. The authors thank Drs. Mays, Hymens, Mansfield, and the staff from the Melanoma and Skin Center at the University of Texas MD Anderson Cancer Center for their help during the data collection. This project was sponsored by NIH grant R01 CA106728. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. Authors' Contributions: Conception and design: A. Garcia-Uribe, J. Zou, M. Duvic, V.G. Prieto, L.V. Wang Development of methodology: J. Zou, L.V. Wang Acquisition of data (provided animals, acquired and managed patients, provided facilities, etc.): A. Garcia-Uribe, J. Zou, M. Duvic, V.G. Prieto Analysis and interpretation of data (e.g., statistical analysis, biostatistics, computational analysis): A. Garcia-Uribe, J. Zou, M. Duvic, J.H. Cho-Vega, L.V. Wang Writing, review, and/or revision of the manuscript: A. Garcia-Uribe, J. Zou, M. Duvic, J.H. Cho-Vega, V.G. Prieto, L.V. Wang. Administrative, technical, or material support (i.e., reporting or organizing data, constructing databases): A. Garcia-Uribe, J. Zou Study supervision: J. Zou, M. Duvic, L.V. Wang Identified the patients, made the clinical assessments, helped to design the study, and reviewed the images: M. Duvic L.V. Wang has ownership interest (including patents). No potential conflicts of interest were disclosed by the other authors.

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Accepted Version - nihms-369811.pdf


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