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Published August 2018 | Accepted Version
Journal Article Open

Recent progress in photoacoustic molecular imaging


By acoustically detecting the optical absorption contrast, photoacoustic (PA) tomography (PAT) has broken the penetration limits of traditional high-resolution optical imaging. Through spectroscopic analysis of the target's optical absorption, PAT can identify a wealth of endogenous and exogenous molecules and thus is inherently capable of molecular imaging with high sensitivity. PAT's molecular sensitivity is uniquely accompanied by non-ionizing radiation, high spatial resolution, and deep penetration in biological tissues, which other optical imaging modalities cannot achieve yet. In this concise review, we summarize the most recent technological advancements in PA molecular imaging and highlight the novel molecular probes specifically made for PAT in deep tissues. We conclude with a brief discussion of the opportunities for future advancements.

Additional Information

© 2018 Elsevier Ltd. Available online 7 April 2018. This work was supported in part by National Institutes of Health grants DP1 EB016986 (NIH Director's Pioneer Award), R01 CA186567 (NIH Director's Transformative Research Award), R01 EB016963, U01 NS090579 (BRAIN Initiative), and U01 NS099717 (BRAIN Initiative) as well as National Science Foundation grant 1255930 (all to L.W.), and by Duke MEDx research fund and startup fund (to J.Y.). The authors appreciate Emelina Vienneau's kind help with editing the manuscript. L.W. has a financial interest in Microphotoacoustics, Inc., CalPACT, LLC, and Union Photoacoustic Technologies, Ltd., which, however, did not support this work.

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Accepted Version - nihms957317.pdf


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August 19, 2023
October 18, 2023