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Published October 27, 2008 | Published
Journal Article Open

Realtime Photoacoustic Microscopy of Murine Cardiovascular Dynamics


Non-invasive visualization of cardiovascular dynamics in small animals is challenging due to their rapid heart-rates. We present a realtime photoacoustic imaging system consisting of a 30-MHz ultrasound array transducer, receive electronics, a high-repetition-rate laser, and a multicore-computer, and demonstrate its ability to image optically-absorbing structures of the beating hearts of young athymic nude mice at rates of ~50 frames per second with 100 µm×25 µm spatial resolution. To our knowledge this is the first report of realtime photoacoustic imaging of physiological dynamics.

Additional Information

© 2008 Optical Society of America. Received 10 Jun 2008; revised 8 Aug 2008; accepted 10 Aug 2008; published 24 Oct 2008. We thank the NIH transducer resource group for their work in fabrication of the high-frequency ultrasound transducer. This work was supported by NIH grants R01 EB000712 and R01 NS46214.

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Published - oe-16-22-18551.pdf


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