Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published December 2015 | Published
Journal Article Open

Photoacoustic tomography of vascular compliance in humans


Characterization of blood vessel elastic properties can help in detecting thrombosis and preventing life-threatening conditions such as acute myocardial infarction or stroke. Vascular elastic photoacoustic tomography (VE-PAT) is proposed to measure blood vessel compliance in humans. Implemented on a linear-array-based photoacoustic computed tomography system, VE-PAT can quantify blood vessel compliance changes due to simulated thrombosis and occlusion. The feasibility of the VE-PAT system was first demonstrated by measuring the strains under uniaxial loading in perfused blood vessel phantoms and quantifying their compliance changes due to the simulated thrombosis. The VE-PAT system detected a decrease in the compliances of blood vessel phantoms with simulated thrombosis, which was validated by a standard compression test. The VE-PAT system was then applied to assess blood vessel compliance in a human subject. Experimental results showed a decrease in compliance when an occlusion occurred downstream from the measurement point in the blood vessels, demonstrating VE-PAT's potential for clinical thrombosis detection.

Additional Information

© 2015 SPIE. Paper 150611R received Sep. 11, 2015; accepted for publication Nov. 19, 2015; published online Dec. 21, 2015. We thank Alejandro Garcia-Uribe for his assistance in human experiments and Professor James Ballard for a close reading of this paper. This work was sponsored by the National Institutes of Health Grants DP1 EB016986 (NIH Director's Pioneer Award), R01 CA186567 (NIH Director's Transformative Research Award), and S10 RR026922. L. V. Wang has a financial interest in Endra, Inc., and Microphotoacoustics, Inc., which, however, did not support this work.

Attached Files

Published - JBO_20_12_126008.pdf


Files (2.7 MB)
Name Size Download all
2.7 MB Preview Download

Additional details

August 22, 2023
October 20, 2023