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Published March 15, 2012 | Supplemental Material + Accepted Version
Journal Article Open

MR-guided stereotactic navigation


Functional magnetic resonance imaging allows precise localization of brain regions specialized for different perceptual and higher cognitive functions. However, targeting these deep brain structures for electrophysiology still remains a challenging task. Here, we propose a novel framework for MRI-stereotactic registration and chamber placement for precise electrode guidance to recording sites defined in MRI space. The proposed "floating frame" approach can be used without usage of ear bars, greatly reducing pain and discomfort common in standard stereotactic surgeries. Custom pre-surgery planning software was developed to automatically solve the registration problem and report the set of parameters needed to position a stereotactic manipulator to reach a recording site along arbitrary, non-vertical trajectories. Furthermore, the software can automatically identify blood vessels and assist in finding safe trajectories to targets. Our approach was validated by targeting different regions in macaque monkeys and rats. We expect that our method will facilitate recording in new brain areas and provide a valuable tool for electrophysiologists.

Additional Information

© 2011 Elsevier B.V. Received 23 May 2011. Revised 29 November 2011. Accepted 30 November 2011. Available online 13 December 2011.

Attached Files

Accepted Version - Planner_2_Nov_2011_Revision_SO_WithFig.pdf

Accepted Version - nihms-1697631.pdf

Supplemental Material - mmc5.mp4


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