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Published May 18, 2001 | public
Journal Article

Interactions of the COP9 Signalosome with the E3 Ubiquitin Ligase SCF^(TIR1) in Mediating Auxin Response


The COP9 signalosome is an evolutionary conserved multiprotein complex of unknown function that acts as a negative regulator of photomorphogenic seedling development in Arabidopsis. Here, we show that plants with reduced COP9 signalosome levels had decreased auxin response similar to loss-of-function mutants of the E3 ubiquitin ligase SCF^(TIR1). Furthermore, we found that the COP9 signalosome and SCF^(TIR1) interacted in vivo and that the COP9 signalosome was required for efficient degradation of PSIAA6, a candidate substrate of SCF^(TIR1). Thus, the COP9 signalosome may play an important role in mediating E3 ubiquitin ligase–mediated responses.

Additional Information

© 2001 American Association for the Advancement of Science. 12 February 2001; accepted 10 April 2001. Published online 3 May 2001; 10.1126/science.1059776. Include this information when citing this paper. We thank the Arabidopsis Biological Resource Center at Ohio State University for expressed sequence tag clones. This work was supported by a NSF grant (MCD-0077217) to X.-W.D. C.S. is a postdoctoral fellow of the Deutsche Forschungsgemeinschaft (Schw751/1-1), G.S. was a fellow of the Istituto Pasteur-Fondazione Cenci-Bolognetti, and X.-W.D. is a NSF Presidential Faculty Fellow.

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August 19, 2023
October 18, 2023