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Published March 2006 | Published
Journal Article Open

A Born-type approximation method for bioluminescence tomography


In this paper, we present a Born-type approximation method for bioluminescence tomography (BLT), which is to reconstruct an internal bioluminescent source from the measured bioluminescent signal on the external surface of a small animal. Based on the diffusion approximation for the photon propagation in biological tissue, this BLT method utilizes the Green function to establish a linear relationship between the measured bioluminescent signal and the internal bioluminescent source distribution. The Green function can be modified to describe a heterogeneous medium with an arbitrary boundary using the Born approximation. The BLT reconstruction is formulated in a linear least-squares optimization framework with simple bounds constraint. The performance of this method is evaluated in numerical simulation and phantom experiments.

Additional Information

© 2006 American Association of Physicists in Medicine. Received 21 October 2004; revised 25 December 2005; accepted for publication 28 December 2005; published 21 February 2006. This work is supported by NIH/NIBIB Grant No. EB001685.

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Published - Cong_2006p679.pdf


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