Published March 1995
| public
Journal Article
Tuning the response of a pH-sensitive membrane switch
- Creators
- Thomas, James L.
- You, Hong
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Tirrell, David A.
Abstract
We have shown that the hydrophobic polyelectrolyte poly-(2-ethylacrylic acid) (PEAA, 1) causes destabilization of lipid bilayer membranes at pH 6.55 or lower and that this pH-sensitive [compound 1] response can be used to trigger release of hydrophilic compounds entrapped in liposomes. Responsive membrane systems are finding increasingly important applications in drug delivery, signal amplification in biochemical assay, and molecular recognition.
Additional Information
© 1995 American Chemical Society. Received November 14, 1994. This work was supported by grants from the NSF Materials Research Laboratory at the University of Massachusetts and from the U.S. Army Research Office.Additional details
- Eprint ID
- 53482
- DOI
- 10.1021/ja00115a039
- Resolver ID
- CaltechAUTHORS:THOjacs1995
- NSF
- Army Research Office (ARO)
- Created
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2015-01-29Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field