Structures of two classes of MHC molecules elucidated: crucial differences and similarities
New structures of MHC molecules have significantly improved our understanding of molecular recognition in cellular immunology. Highlights include the first structure of a class II MHC molecule, complexed with a viral peptide and with a bacterial superantigen. A structure of an MHC-like Fc receptor is expected soon. Interesting comparisons can now be made between the recognition properties of MHC and MHC-like proteins.
© 1994 Current Biology Ltd. We thank Kirsten Fischer Lindahl and her colleagues for communicating data before publication and Larry Stern and Ted Jardetzky for the DR1 coordinates. Wim Burmeister is supported by an EMBO fellowship. Work in the authors' laboratory is supported by the Howard Hughes Medical Institute (PJB) and a grant from the Arthritis Foundation (PJB).