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Published April 22, 2013 | Published
Journal Article Open

Slow-sound photoacoustic microscopy


We propose to enhance the axial resolution of photoacoustic microscopy (PAM) by reducing the speed of sound within the imaging region of interest. With silicone oil immersion, we have achieved a finest axial resolution of 5.8 μm for PAM, as validated by phantom experiments. The axial resolution was also enhanced in vivo when mouse ears injected with silicone oil were imaged. When tissue-compatible low-speed liquid becomes available, this approach may find broad applications in PAM as well as in other imaging modalities, such as photoacoustic computed tomography and ultrasound imaging.

Additional Information

© 2013 AIP Publishing LLC. Received 25 February 2013; accepted 15 April 2013; published online 26 April 2013. This work was sponsored in part by National Institutes of Health Grant Nos. DP1 EB016986 (NIH Director's Pioneer Award), R01 CA134539, U54 CA136398, R01 CA157277, and R01 CA159959. L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.

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