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Published March 15, 2013 | Published
Journal Article Open

High-sensitivity ultrasound-modulated optical tomography with a photorefractive polymer


By detecting ultrasonically tagged diffuse light, ultrasound-modulated optical tomography images optical contrast with ultrasonic resolution deep in turbid media, such as biological tissue. However, small detection etendues and weak tagged light submerged in strong untagged background light limit the signal detection sensitivity. In this Letter, we report the use of a large-area (∼5 cm×5 cm ) photorefractive polymer film that yields more than 10 times detection etendue over previous detection schemes. Our polymer-based system enabled us to resolve absorbing objects embedded inside diffused media thicker than 80 transport mean free paths, by using moderate light power and short ultrasound pulses.

Additional Information

© 2013 Optical Society of America. Received November 26, 2012; revised January 30, 2013; accepted February 10, 2013; posted February 11, 2013 (Doc. ID 179976); published March 12, 2013. We thank Nitto Denko Technical (Oceanside, California) for providing the PRP for this research. This work was sponsored in part by National Academies Keck Futures Initiative grant IS 13 and National Institutes of Health grants DP1 EB016986 (NIH Director's Pioneer Award), R01 EB000712, and U54 CA136398.

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