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Published February 20, 2004 | Erratum + Published
Journal Article Open

Signal dependence and noise source in ultrasound-modulated optical tomography


A Monte Carlo modeling technique was used to simulate ultrasound-modulated optical tomography in inhomogeneous scattering media. The contributions from two different modulation mechanisms were included in the simulation. Results indicate that ultrasound-modulated optical signals are much more sensitive to small embedded objects than unmodulated intensity signals. The differences between embedded absorption and scattering objects in the ultrasound-modulated optical signals were compared. The effects of neighboring inhomogeneity and background optical properties on the ultrasound-modulated optical signals were also studied. We analyzed the signal-to-noise ratio in the experiment and found that the major noise source is the speckle noise caused by small particle movement within the biological tissue sample. We studied this effect by incorporating a Brownian motion factor in the simulation.

Additional Information

© 2004 Optical Society of America. Received 20 August 2003; revised manuscript received 17 November 2003; accepted 21 November 2003. This project was sponsored by a Summer Faculty Research Fellowship (for G. Yao) from the University of Missouri-Columbia and in part (for L. V. Wang) by National Institutes of Health grant R01 CA71980, National Science Foundation grant BES-9734491, and Texas Higher Education Coordinating Board grant 000512-0063-2001.


Gang Yao and Lihong V. Wang, "Signal dependence and noise source in ultrasound-modulated optical tomography: erratum," Appl. Opt. 45, 1288-1288 (2006)

Attached Files

Published - ao-43-6-1320.pdf

Erratum - ao-45-6-1288.pdf


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