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Published March 16, 2016 | Accepted Version + Supplemental Material
Journal Article Open

Critical Points in Tumorigenesis: A Carcinogen-Initiated Phase Transition Analyzed via Single-Cell Proteomics


A kinetic, single-cell proteomic study of chemically induced carcinogenesis is interpreted by treating the single-cell data as fluctuations of an open system transitioning between different steady states. In analogy to a first-order transition, phase coexistence and the loss of degrees of freedom are observed. The transition is detected well before the appearance of the traditional biomarker of the carcinogenic transformation.

Additional Information

© 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Received: April 27, 2015; Revised: November 9, 2015; First published: 18 January 2016. S.K.P. and N.K.-B. contributed equally to this work. S.K.P. and J.R.H. conceived and designed the project. S.K.P. planned and carried out the research. N.K.B. and R.D.L. developed the theory. N.K.B. performed the theoretical analysis with inputs from other authors. Y.S.S. contributed to reagent/analysis tools. S.K.P., N.K.B., R.D.L. and J.R.H., were involved in discussion of results and in preparing the manuscript. The authors are grateful to Rudi Balling, Alexander Skupin and Yaron Antebi for their detailed and insightful discussion and comments on the contents of the manuscript. This work is funded by the National Cancer Institute through grant 5U54 CA119347, the Jean Perkins Foundation, the Ben and Catherine Ivy Foundation, and an Intermobility grant Sinc-Prot; 2013 from Fonds National de la Recherche Luxembourg, Grand Duchy of Luxembourg.

Attached Files

Accepted Version - nihms787687.pdf

Supplemental Material - smll201501178-sup-0001-S1.pdf


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