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Published June 1, 1940 | public
Journal Article Open

The Course of Thiamin Metabolism in Man as Indicated by the Use of Radioactive Sulfur


When supplementary thiamin (Vitamin B1) is ingested or injected, the amount which appears in the urine during the succeeding twenty-four hours usually increases, but the total additional excretion always falls short of the supplement, even when the vitamin is injected and there can be no question of incomplete absorption. We have sought information on this unaccounted-for moiety by synthesizing thiamin from sulfur which contains the radioactive isotope S35 (designated as B1*) and by following, after injection of the B1*, the excretion of the radiosulfur (S*) in the urine and feces and the excretion of total free B1 in the urine.

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Copyright © 1940 by the National Academy of Sciences. Communicated April 23, 1940. This work was aided by grants from the National Research Council, the Research Corporation, the Hixon Fund and the Globe Mills Fund (California Institute of Technology). This paper was presented at the meeting of the American Society of Biological Chemists in New Orleans, March 14-16, 1940.


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