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Published February 28, 2008 | Published
Book Section - Chapter Open

Optical-resolution confocal photoacoustic microscopy


A confocal photoacoustic microscope with improved lateral resolution has been developed by employing stronglyfocused bright field optical illumination and spherically focused 75-MHz ultrasonic detection. The lateral resolution was experimentally measured to be 5 μm and the axial resolution was estimated to be 15 μm. The maximum imaging depth was demonstrated to be greater than 0.7 mm. In in vivo experiments, microvessels with a diameter of ~ 5 μm are imaged in small animals.

Additional Information

© 2008 Society of Photo-Optical Instrumentation Engineers (SPIE). This project is sponsored in part by National Institutes of Health Grant Nos. R01 CA106728 and R01 NS46214 (BRP).

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January 14, 2024