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Published November 16, 2017 | Accepted Version + Published
Journal Article Open

A Forward-Adjoint Operator Pair Based on the Elastic Wave Equation for Use in Transcranial Photoacoustic Computed Tomography


Photoacoustic computed tomography (PACT) is an emerging imaging modality that exploits optical contrast and ultrasonic detection principles to form images of the photoacoustically induced initial pressure distribution within tissue. The PACT reconstruction problem corresponds to an inverse source problem in which the initial pressure distribution is recovered from measurements of the radiated wavefield. A major challenge in transcranial PACT brain imaging is compensation for aberrations in the measured data due to the presence of the skull. Ultrasonic waves undergo absorption, scattering, and longitudinal-to-shear wave mode conversion as they propagate through the skull. To properly account for these effects, a wave-equation-based inversion method should be employed that can model the heterogeneous elastic properties of the skull. In this work, a forward model based on a finite-difference time-domain discretization of the three-dimensional elastic wave equation is established and a procedure for computing the corresponding adjoint of the forward operator is presented. Massively parallel implementations of these operators employing multiple graphics processing units are also developed. The developed numerical framework is validated and investigated in computer-simulation and experimental phantom studies whose designs are motivated by transcranial PACT applications.

Additional Information

© 2017, Society for Industrial and Applied Mathematics. Submitted: 12 December 2016. Accepted: 15 May 2017. Published online: 16 November 2017. The work of the authors was supported in part by NIH awards EB01696301 and 5T32EB01485505 and NSF award DMS1614305.

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Published - 16m1107619.pdf

Accepted Version - 1709.02733.pdf


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