Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published 2014 | public
Book Section - Chapter

High-speed photoacoustic tomography


Traditional diagnostic imaging technologies—including ultrasound, x-ray computed tomography, and magnetic resonance imaging—have dramatically improved patient care in the clinic. However, these technologies still have limited ability to detect small lesions. In most cases, the detectable lesions are ~1 cm in dimeter, corresponding to ~10^9 cells (including circulating and microscopic metastatic deposits) and representing ~2/3 of the natural history of a cancer [1]. Consequently, the window of opportunity for treatment before a tumor reaches its lethal state is narrow. Hence, it is imperative to develop novel technologies capable of detecting neoplasia early. Non ionizing biomedical optical imaging is highly desirable because of its rich contrast. In particular, optical absorption—to which photoacoustic tomography is sensitive—can be used to obtain physiological parameters such as the total concentration and oxygenation of hemoglobin is related to hyper-metabolism. Since both angiogenesis and hypermetabolism are hallmarks of cancer, photoacoustic tomography can potentially provide early-cancer detection.

Additional Information

© 2014 Taylor & Francis Group, LLC.

Additional details

August 19, 2023
October 19, 2023