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Published April 2022 | Published
Journal Article Open

A mechanochemical two for one: Mechanical activation of norborn‐2‐en‐7‐one releases carbon monoxide and switches on aggregation‐induced emission


Mechanical forces are typically considered to be destructive in polymeric materials, leading to degradation via nonspecific chain scission. However, the emergence of the mechanophore hypothesis has enabled the design of polymers that are able to harness these typically destructive forces and convert them into productive chemical transformations. Stress-sensitive molecules called mechanophores have been developed to achieve a wide range of functional responses including changes in color or luminescence, which are particularly desirable for applications in stress sensing. Mechanophores that release functional small molecules in response to mechanical force are also emerging as an important target of investigation. Addressing both of these areas, Moore and co-workers recently reported a norborn-2-en-7-one (NEO) mechanophore that releases carbon monoxide (CO) with concomitant fluorogenesis. CO is recognized as an important biological signaling molecule and potential therapeutic agent; however, strategies for safely delivering CO are needed because administration is difficult to control in clinical settings. The ability to remotely activate mechanophores using focused ultrasound, combined with a multimechanophore approach that permits the release of a large number of cargo molecules, make this discovery potentially promising for future CO-based therapies.

Additional Information

© 2022 The Authors. Aggregate published by SCUT, AIEI, and John Wiley & Sons Australia, Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Issue Online: 24 April 2022; Version of Record online: 04 April 2022; Manuscript accepted: 20 March 2022; Manuscript received: 18 March 2022. We gratefully acknowledge financial support from the Arnold and Mabel Beckman Foundation through a Beckman Young Investigator Award. The authors declare no conflict of interest.

Attached Files

Published - Aggregate_-_2022_-_Barber_-_A_mechanochemical_two_for_one_Mechanical_activation_of_norborn‐2‐en‐7‐one_releases_carbon.pdf



Additional details

August 22, 2023
October 24, 2023