Animal models for studying neural crest development: is the mouse different?
The neural crest is a uniquely vertebrate cell type and has been well studied in a number of model systems. Zebrafish, Xenopus and chick embryos largely show consistent requirements for specific genes in early steps of neural crest development. By contrast, knockouts of homologous genes in the mouse often do not exhibit comparable early neural crest phenotypes. In this Spotlight article, we discuss these species-specific differences, suggest possible explanations for the divergent phenotypes in mouse and urge the community to consider these issues and the need for further research in complementary systems.
© 2015 Published by The Company of Biologists Ltd. Received January 7, 2015. Accepted March 11, 2015. R.M. is supported by grants from the Medical Research Council [MR/J000655/1] and Wellcome Trust. E.H.B. is supported by a Quantissue Fellowship . M.B. is supported by National Institutes of Health grants [DE024157 and HD037105]. P.A.T. is supported by the Stowers Institute for Medical Research and the National Institute of Dental and Craniofacial Research [DE 016082].
Published - Development-2015-Barriga-1555-60.pdf