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Published January 1998 | public
Journal Article

Ultrasonic Modulation of Scattered Light in Turbid Media and a Potential Novel Tomography in Biomedicine


Ultrasonic modulation of scattered laser light was used to image objects buried in tissue-simulating turbid media. The ultrasonic wave focused into the turbid media modulated the laser light passing through the ultrasonic field. The modulated laser light collected by a photomultiplier tube reflected primarily the local mechanical and optical properties in the zone of ultrasonic modulation. A raster scanning over a heterogeneous turbid medium yielded an image of the medium based on the ultrasound-modulated optical signal. The detectability of modulated signal was estimated using diffusion theory. The dependence of the modulated signal on the off-axis distance of the detector from the optic axis and on the amplitude of ultrasound was studied. The mechanisms of ultrasonic modulation of scattered light are discussed. A theory based on the field autocorrelation function is reviewed as well.

Additional Information

© 1998 American Society for Photobiology. Received 15 April 1997; accepted 2 October 1997. We thank X. Zhao and Q. Shen for their experimental assistance. This project was sponsored in part by National Institutes of Health grants R29 CA68562 and R01 CA71980 and The Whitaker Foundation grant.

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