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Published April 2011 | Accepted Version
Journal Article Open

High-Transmission-Efficiency and Side-Viewing Micro OIDRS Probe for Fast and Minimally Invasive Tumor Margin Detection


The determination of a cancer free margin I organ is a difficult and time consuming process, with an unmet need for rapid determination of tumor margin at surgery. In this paper, we report the design, fabrication, and testing of a novel miniaturized optical sensor probe with "side-viewing" capability. Its unprecedented small size, unique "side-viewing" capability, and high optical transmission efficiency enable the agile maneuvering and efficient data collection even in the narrow cavities inside the human body. The sensor probe consists of four micromachined substrates with optical fibers for oblique light incidence and collection of spatially resolved diffuse reflectance from the contacted tissues. The optical sensor probe has been used to conduct the oblique incidence diffuse reflectance spectroscopy (OIDRS) on a human pancreatic specimen. Based on the measurement results, the margin of the malignant tumor has been successfully determined optically, which matches well with the histological results.

Additional Information

© 2010 IEEE. Manuscript received April 26, 2010; revised July 05, 2010; accepted August 20, 2010. Date of publication September 27, 2010; date of current version February 04, 2011. This work was supported by the National Institute of Health under Grant R01 CA106728. The associate editor coordinating the review of this paper and approving it for publication was Prof. Okyay Kaynak.

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Accepted Version - nihms-264728.pdf


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