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Published June 2012 | Published
Journal Article Open

Aberration correction for transcranial photoacoustic tomography of primates employing adjunct image data


A challenge in photoacoustic tomography (PAT) brain imaging is to compensate for aberrations in the measured photoacoustic data due to their propagation through the skull. By use of information regarding the skull morphology and composition obtained from adjunct x-ray computed tomography image data, we developed a subject-specific imaging model that accounts for such aberrations. A time-reversal-based reconstruction algorithm was employed with this model for image reconstruction. The image reconstruction methodology was evaluated in experimental studies involving phantoms and monkey heads. The results establish that our reconstruction methodology can effectively compensate for skull-induced acoustic aberrations and improve image fidelity in transcranial PAT.

Additional Information

© 2012 SPIE. Paper 12034 received Jan. 13, 2012; revised manuscript received Apr. 9, 2012; accepted for publication Apr. 12, 2012; published online Jun. 5, 2012. Chao Huang, Robert W. Schoonover, and Mark A. Anastasio acknowledge support in part by NIH awards EB010049 and EB009715. Liming Nie, Zijian Guo, and Lihong V. Wang acknowledges support by the NIH awards EB010049, CA134539, EB000712, CA136398, and EB008085. L.V.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.

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