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Published April 2023 | Published
Journal Article Open

Location-Dependent Spatiotemporal Antialiasing in Photoacoustic Computed Tomography

  • 1. ROR icon California Institute of Technology


Photoacoustic computed tomography (PACT) images optical absorption contrast by detecting ultrasonic waves induced by optical energy deposition in materials such as biological tissues. An ultrasonic transducer array or its scanning equivalent is used to detect ultrasonic waves. The spatial distribution of the transducer elements must satisfy the spatial Nyquist criterion; otherwise, spatial aliasing occurs and causes artifacts in reconstructed images. The spatial Nyquist criterion poses different requirements on the transducer elements' distributions for different locations in the image domain, which has not been studied previously. In this research, we elaborate on the location dependency through spatiotemporal analysis and propose a location-dependent spatiotemporal antialiasing method. By applying this method to PACT in full-ring array geometry, we effectively mitigate aliasing artifacts with minimal effects on image resolution in both numerical simulations and in vivo experiments.

Copyright and License

© 2023 IEEE.


This work was supported by the National Institutes of Health under grants R01 NS102213, U01 NS099717 (BRAIN Initiative), U01 EB029823 (BRAIN Initiative), and R35 CA220436 (Outstanding Investigator Award). This work involved human subjects or animals in its research. Approval of all ethical and experimental procedures and protocols was granted by the Institutional Review Board of the California Institute of Technology, and performed in line with the Declaration of Helsinki. The authors would like to thank Li Lin for his helpful discussion in this study.

Conflict of Interest

Lihong V. Wang has financial interests in Microphotoacoustics, Inc., CalPACT, LLC, and Union Photoacoustic Technologies, Ltd., which did not support this work.


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Additional details

April 8, 2024
April 8, 2024