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Published October 1, 2003 | Published
Journal Article Open

Three-dimensional laser-induced photoacoustic tomography of mouse brain with the skin and skull intact


Three-dimensional laser-induced photoacoustic tomography, also referred to as optoacoustic tomography, is developed to image animal brain structures noninvasively with the skin and skull intact. This imaging modality combines the advantages of optical contrast and ultrasonic resolution. The distribution of optical absorption in a mouse brain is imaged successfully. The intrinsic optical contrast reveals not only blood vessels but also other detailed brain structures, such as the cerebellum, hippocampus, and ventriculi lateralis. The spatial resolution is primarily diffraction limited by the received photoacoustic waves. Imaged structures of the brain at different depths match the corresponding histological pictures well.

Additional Information

© 2003 Optical Society of America. Received March 11, 2003. This study was sponsored in part by the U.S. Department of Defense, the National Institutes of Health, the National Science Foundation, and the Texas Advanced Research Program.

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