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Published February 17, 2011 | Published
Book Section - Chapter Open

Integrated photoacoustic and fluorescence confocal microscopy


Optical-resolution photoacoustic microscopy has demonstrated utility in imaging and characterizing microvasculature networks in vivo. This work presents a novel imaging system that integrates optical-resolution photoacoustic microscopy and fluorescence confocal microscopy for simultaneous photoacoustic and fluorescence imaging. The integrated system can acquire intrinsically registered photoacoustic and fluorescence images in a single scan. Capable of providing micrometer scale microscopic imaging of both optical absorption and fluorescence contrasts, the system demonstrates in vivo imaging of oxygen saturation and oxygen partial pressure in mouse ears.

Additional Information

© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). We thank C. Zhang for helping with data processing and manuscript preparation, and Professor J. Ballard for careful proofreading. This work was sponsored in part by National Institutes of Health (NIH) grants R01 EB000712, R01 EB008085, R01 CA134539, U54 CA136398, and 5P60 DK02057933. L. Wang has a financial interest in Microphotoacoustics, Inc., and Endra, Inc., which, however, did not support this work.

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