Functional Analysis of the TAN-1 Gene, a Human Homolog of Drosophila Notch
Abstract
The TAN-1 gene was originally discovered at the breakpoint of a recurrent (7;9)(q34;q34.3) chromosomal translocation found in a subset of human T-lymphoblastic leukemias (Reynolds et al. 1987; Smith et al. 1988; Ellisen et al. 1991). This translocation joins roughly the 3′ half of TAN-1 head-to-head with the 3′ portion of the β T-cell-receptor gene (TCRB) beginning at the 5′ boundary of one or the other J segment. Intact TAN-1 is normally transcribed into an 8.2-kb transcript that is present in many tissues, most abundantly in developing thymus and spleen (Ellisen et al. 1991). This tissue distribution and the apparent involvement of an altered version of the gene in T-cell cancers have suggested that TAN-1 normally has some special function in lymphocytes or their precursors.
Additional Information
© 1994 Cold Spring Harbor Laboratory Press.Attached Files
Published - 125.full.pdf
Files
Name | Size | Download all |
---|---|---|
md5:13a928327309ba5ad9695ea34da28a5b
|
11.5 MB | Preview Download |
Additional details
- Eprint ID
- 103179
- Resolver ID
- CaltechAUTHORS:20200513-131711374
- Created
-
2020-05-13Created from EPrint's datestamp field
- Updated
-
2021-11-16Created from EPrint's last_modified field